Roma are still decimated by injuries, so Andrea Belotti partners Tammy Abraham in the Europa League semi-final against Bayer Leverkusen.
It kicks off at the Stadio Olimpico at 20.00 UK time (19.00 GMT).
Jose Mourinho has to put more focus on winning the Europa League after falling behind in the race for a top four position in Serie A.
Absentees continue to pile up, missing Stephan El Shaarawy, Chris Smalling, Marash Kumbulla, Diego Llorente and Rick Karsdorp.
Paulo Dybala and Gini Wijnaldum are only fit for a spot on the bench.
Zeki Celik is available after his ban against Inter, but Bryan Cristante has to drop into defence to fill the gaps.
Bayer Leverkusen had been on a 14-game unbeaten run until defeat to FC Koln at the weekend and sit sixth in the Bundesliga under coach Xabi Alonso.
Former Roma striker Patrik Schick is out for the rest of the season, also making this trip without Karim Bellarabi, Callum Hudson-Odoi and Andrey Lunev.
While the Giallorossi lifted the Conference League last season, Leverkusen are looking for their first European Final in 21 years.
Roma: Rui Patricio; Mancini, Cristante, Ibanez; Celik, Matic, Bove, Spinazzola; Pellegrini; Belotti, Abraham
Bayer Leverkusen: Hradecky; Kossounou, E Tapsoba, Tah; Frimpong, Palacios, Andrich, Hincapié; Diaby, Wirtz; Hlozek
Ref: Oliver (ENG)
Player statistic
| 50' |  |
Robert Andrich | ||
| 57' | |
Moussa Diaby | ||
| Gianluca Mancini | |
58' | ||
| 58' | |
Jonathan Tah | ||
| Edoardo Bove |  |
63' | ||
| Tammy Abraham | |
76' | ||
| Roger Ibañez | |
89' | ||
| Leonardo Spinazzola | |
90+3' |
Match statistic
