Atalanta again look to Luis Muriel and Ruslan Malinovskyi as they visit a Bayer Leverkusen side forced to reshuffle in the Europa League Round of 16.
The first leg ended 3-2 for La Dea in Bergamo and the away goals rule no longer applies, so it’s even more of a positive result than it might’ve been in the past.
The second leg kicks off in Leverkusen at 17.45 GMT, you can follow all the build-up and action as it happens from this game and Roma-Vitesse on the LIVEBLOG.
Europa and Conference Liveblog: Bayer Leverkusen-Atalanta and Roma-Vitesse
Both these sides have injury concerns to deal with going in, as Duvan Zapata and Josip Ilicic remain unavailable.
That means Muriel is the only genuine striker and he scored twice in the first leg, supported again by Malinovskyi and Teun Koopmeiners.
The good news for Atalanta is only once this season have they lost by more than one clear goal, against Roma in December.
Bayer Leverkusen lost Jeremie Frimpong and teenage sensation Florian Wirtz to serious injuries during their 1-0 home defeat to FC Koln at the weekend, as both of them are ruled out for the season.
Patrik Schick is also a long-term absentee, but Robert Andrich and Karim Bellarabi are back in the squad, with Kerem Demirbay available after missing the first leg through suspension.
As expected, the Germans are starting with three at the back, a tactical shift in Bergamo that changed the game and helped neutralise Atalanta’s attacks.
Bayer Leverkusen: Hradecky; Tah, Tapsoba, Hincapié; Fosu-Mensah, Demirbay, Palacios, Aranguiz, Bakker; Diaby, Adli
Bayer Leverkusen bench: Grill, Lomb, Kossounou, Paulinho, Andrich, Azmoun, Alario, Sinkgraven, Bellarabi
Atalanta: Musso; Toloi, Demiral, Palomino; Hateboer, De Roon, Freuler, Zappacosta; Koopmeiners; Malinovskyi, Muriel
Atalanta bench: Rossi, Sportiello, Maehle, Boga, Pezzella, Djimsiti, Mihaila, Pessina, Scalvini, Pasalic
Ref: Letexier (FRA)