Milan look to Nikola Kalinic, Suso and Fabio Borini in the Coppa Italia semi-final, while Lazio have Ciro Immobile back in the starting XI.
The first leg kicks off at San Siro at 19.45 GMT, follow the build-up and action as it happens on the LIVEBLOG.
These sides met on Sunday and Milan won 2-1, although the Aquile were furious that VAR technology missed Patrick Cutrone scoring with his arm.
Milan look to Nikola Kalinic, Suso and Fabio Borini in the Coppa Italia semi-final, while Lazio have Ciro Immobile back in the starting XI.
The first leg kicks off at San Siro at 19.45 GMT, follow the build-up and action as it happens on the LIVEBLOG.
These sides met on Sunday and Milan won 2-1, although the Aquile were furious that VAR technology missed Patrick Cutrone scoring with his arm.
Immobile missed that game due to injury, but the Serie A Capocannoniere returns with support from Felipe Anderson and Sergej Milinkovic-Savic, resting Luis Alberto.
Stefan de Vrij and Davide Di Gennaro are on the treatment table, so Martin Caceres gets his first start in a Lazio jersey.
Milan miss Ricardo Rodriguez, Andrea Conti and Marco Storari, but Nikola Kalinic is back in the starting XI after his muscular issue, flanked by Suso and Jack Bonaventura.
Former Lazio midfielder Lucas Biglia also starts, but Borini appears to be re-routed as a left-back.
Biglia, Cutrone, Manuel Locatelli and Lazio goalkeeper Thomas Strakosha are one yellow card away from missing the second leg.
Milan: G Donnarumma; Abate, Bonucci, Romagnoli, Borini; Kessie, Biglia, Locatelli; Suso, Kalinic, Bonaventura
Milan bench: Guarnone, A Donnarumma, Calabria, Bellanova, Musacchio, Zapata, Calhanoglu, Mauri, Montolivo, Cutrone, André Silva
Lazio: Strakosha; Caceres, Luiz Felipe, Radu; Basta, Parolo, Leiva, Milinkovic-Savic, Lukaku; Felipe Anderson; Immobile
Lazio bench: Guerrieri, Vargic, Patric, Wallace, Bastos, Marusic, Murgia, Jordao, Lulic, Luis Alberto, Nani, Pedro Neto, Caicedo
Ref: Guida