Lazio look to Ciro Immobile and Mattia Zaccagni for this drop down to the Conference League against CFR Cluj, whose goalkeeper is Italian Simone Scuffet.
The play-off kicks off at the Stadio Olimpico in Rome at 20.00 GMT.
The Biancocelesti finished third in their Europa League group and are eager to make up for that disappointing outcome in the Conference League, which was won by their city rivals Roma last season.
Alessio Romagnoli and Stefan Radu are injured, so Patric steps into defence, while Mattia Zaccagni starts because he is suspended for this weekend in Serie A.
Immobile continues to seek a return to full fitness after muscular problems over the last few months.
Romanian side CFR Cluj have Dan Petrescu as their coach and former Udinese goalkeeper Scuffet wearing the gloves.
They just lost the domestic leadership after back-to-back defeats.
Lazio: Maximiano; Lazzari, Patric, Casale, Hysaj; Milinkovic Savic, Marcos Antonio, Vecino; Felipe Anderson, Immobile, Zaccagni
CFR Cluj: Scuffet; Manea, Matias, Burca, Camora; Deac, N Boateng, Muhar, Krasniqi; Yeboah, Birligea
Player statistic
| Patric |  |
15' | ||
| Mattia Zaccagni |  |
39' | ||
| 41' | |
Nana Boateng | ||
| Sergej Milinkovic-Savic | |
44' | ||
| Ciro Immobile (Assist: Felipe Anderson) |
 |
45+4' | ||
| 45+3' | |
Yuri Matias |
| Elseid Hysaj | |
49' | ||
| 79' | |
Ovidiu Hoban |
Match statistic
