Fiorentina are on the verge of Conference League Round of 16 qualification and pick Arthur Cabral to lead the attack against Sporting Braga.
It kicks off at the Stadio Artemio Franchi at 20.00 GMT.
The Viola won the first leg 4-0 in Portugal with a brace each from Luka Jovic and Arthur Cabral, so it will take something spectacular for them to slip up in this play-off.
Lorenzo Venuti and Vitor Tormena are both suspended for the second leg, while Nikola Milenkovic is injured and Sofyan Amrabat rested.
Vincenzo Italiano has done far better in cup competitions this season than in Serie A, already reaching the Coppa Italia semi-final against Cremonese.
Sporting Braga are wearing a special edition of their jersey for this match, with the main sponsor replaced by the Portuguese Red Cross, bringing aid to those affected by the earthquake in Turkey and Syria.
Fiorentina: Sirigu; Dodó, Martinez Quarta, Ranieri, Biraghi; Bianco, Mandragora, Bonaventura, Mandragora; Nico Gonzalez, Cabral, Saponara
Braga: Tiago Sa; Mendes, Niakate, Paulo Oliveira, Cristian Borja; Andre Castro, Pizzi, Rodrigo Gomez; Alvaro Diaglo, Banza, Andre Horta
Player statistic
17' | Castro | |||
34' | Álvaro Djaló (Assist: Simon Banza) | |||
Rolando Mandragora (Assist: Giacomo Bonaventura) |
37' | |||
Dodô | 39' |
Nicólas González | 56' | |||
Riccardo Saponara (Assist: Giacomo Bonaventura) |
58' | |||
Lucas Martínez Quarta | 70' | |||
Cristiano Biraghi | 71' | |||
Arthur Cabral (Assist: Giacomo Bonaventura) |
83' |