Milan hope Rafael Leao and Brahim Diaz can replicate their Serie A performances against Napoli in the Champions League quarter-final, while Eljif Elmas is a False 9 with Kvicha Kvaratskhelia.
It kicks off at San Siro at 20.00 UK time (19.00 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
The second leg will be at the Stadio Diego Armando Maradona on Tuesday April 18 and the away goals system no longer applies, so if they are level on aggregate, it goes to extra time.
These sides met on April 2 in Serie A and Milan emerged 4-0 winners with Rafael Leao’s brace, Brahim Diaz and Alexis Saelemaekers on target, but Napoli have won their last three visits to the Stadio Meazza.
Olivier Giroud is again supported by Leao, Brahim Diaz and Ismael Bennacer, while Pierre Kalulu is only fit enough for the bench.
Zlatan Ibrahimovic, Aster Vranckx, Yacine Adli, Sergino Dest, Ciprian Tatarusanu and Tiemoue Bakayoko are not on the Champions League squad list.
Napoli have an injury crisis in attack, as both Victor Osimhen and his natural replacement Giovanni Simeone are out with muscular issues, while Giacomo Raspadori is not being 100 per cent fit himself.
The only alternative is Elmas as a False 9.
Kvaratskhelia and Hirving Lozano complete the trident, with Matteo Politano on the bench, while Mathias Olivera is benched in favour of Mario Rui.
These players are one yellow card away from missing the second leg: Fode Ballo-Toure, Rade Krunic, Fikayo Tomori, Sandro Tonali, Kim Min-jae, Juan Jesus and Matteo Politano.
Milan: Maignan; Calabria, Kjaer, Tomori, Theo Hernandez; Krunic, Tonali; Brahim Diaz, Bennacer, Leao; Giroud
Milan bench: Mirante, Ballo-Toure, Rebic, Kalulu, Florenzi, Origi, Thiaw, Messias, Pobega, Gabbia, Saelemaekers, De Ketelaere
Napoli: Meret; Di Lorenzo, Rrahmani, Kim Min-jae, Mario Rui; Anguissa, Lobotka, Zielinski; Lozano, Elmas, Kvaratskhelia
Napoli bench: Idasiak, Gollini, Juan Jesus, Olivera, Bereszynski, Politano, Ostigard, Gaetano, Raspadori, Ndombele
Ref: Kovacs (ROU)
Player statistic
| 38' |  |
Piotr Zielinski | ||
| Ismaël Bennacer (Assist: Brahim Díaz) |
 |
40' |
| Ismaël Bennacer | |
61' | ||
| 71' | |
Frank Anguissa | ||
| 71' | |
Giovanni Di Lorenzo | ||
| 74' |  |
Frank Anguissa | ||
| 78' | |
Min-jae Kim | ||
| Alexis Saelemaekers | |
90+3' | ||
| Davide Calabria | |
90+6' | ||
| 90+3' | |
Amir Rrahmani |
Match statistic
