Juventus need to revamp their defence after the Gleison Bremer injury, but Dusan Vlahovic and Teun Koopmeiners start against Cagliari.
It kicks off at the Allianz Juventus Stadium in Turin at 11.30 UK time (10.30 GMT).
You can follow all the action as it happens from today’s five Serie A games on the Liveblog.
The Bianconeri have not conceded a single Serie A goal this season, but ended their run of three straight 0-0 draws by crushing Genoa 3-0.
Above all, midweek they fought back from 2-1 down with 10 men to win 3-2 away to RB Leipzig in the Champions League.
Bremer sustained a serious injury in that match and is out for six months, while Nico Gonzalez, Arkadiusz Milik and Tim Weah are also on the treatment table.
Options are therefore limited for Thiago Motta, who revamps the defence with Pierre Kalulu and Federico Gatti, while Francisco Conceicao starts after his winner in Leipzig.
Notably, Khephren Thuram and youth product Samuel Mbangula get starts rather than Douglas Luiz or Kenan Yildiz.
Cagliari earned their first victory of the campaign by beating Parma 3-2, but have a lot of players still out of action.
They include Leonardo Pavoletti, Gianluca Lapadula, Jakub Jankto and Mateusz Wieteska.
Curiously, Tommaso Augello seems to be placed in a more advanced role, while Zito Luvumbo is benched.
Juventus vs. Cagliari line-ups
Juventus: Di Gregorio; Savona, Kalulu, Gatti, Cambiaso; Locatelli, Thuram; Conceiçao, Koopmeiners, Mbangula; Vlahovic
Cagliari: Scuffet; Zappa, Mina, Luperto, Obert; Makoumbou, Adopo; Zortea, Viola, Augello; Piccoli
