Ciro Immobile leads the Lazio attack with Gustav Isaksen and Pedro, while Cagliari look to Andrea Petagna and Gianluca Lapadula.
It kicks off at the Stadio Olimpico at 17.00 GMT.
The Aquile qualified for the Champions League Round of 16 this week with a 2-0 win over Celtic, sealed by a late brace from substitute Immobile.
However, they are struggling in Serie A with just one point from the last three rounds, including a 2-1 defeat to rock bottom Salernitana.
Mattia Zaccagni, Alessio Romagnoli and Nicolò Casale are still out of action, but Immobile steps in for Taty Castellanos upfront and Pedro gives Felipe Anderson a very rare day off.
Luis Alberto also returns after he missed the Salernitana match through suspension.
Claudio Ranieri’s Cagliari turned a corner with their crazy comeback from 3-0 down to beat Frosinone 4-3, followed by a win over Genoa, narrow defeat to Juventus and draw with Monza.
Alessandro Di Pardo, Marko Rog and Elio Capradossi are long-term absentees, but Petagna is picked upfront with Gianluca Lapadula and support from Nicolas Viola.
Nahitan Nandez is also back in the squad after his injury, but only on the bench.
Lazio: Provedel; Lazzari, Gila, Patric, Marusic; Guendouzi, Rovella, Luis Alberto; Isaksen, Immobile, Pedro
Cagliari: Scuffet; Goldaniga, Dossena, Hatzidiakos; Zappa, Makoumbou, Prati, Azzi; Viola; Petagna, Lapadula
Player statistic
| Pedro (Assist: Manuel Lazzari) |
 |
8' | ||
| 12' |  |
Pantelis Hatzidiakos | ||
| 27' |  |
Antoine Makoumbou |
| 75' | |
Nahitan Nández |
Match statistic
