Inter transform their line-up in Lisbon including chances for Marko Arnautovic, Alexis Sanchez and Davide Frattesi against troubled Benfica.
It kicks off at the Estadio da Luz at 20.00 GMT.
The Nerazzurri already booked their place in the knockouts and will have it out directly with joint leaders Real Sociedad at San Siro in the final game for who gets top spot.
It allows Simone Inzaghi to rotate the squad ahead of this weekend’s Serie A clash with Napoli, not just leaving out injured Denzel Dumfries, Benjamin Pavard and Alessandro Bastoni.
Even Yann Sommer is rested in goal, with Emil Audero making his Inter debut.
Benfica are bottom of the group and already eliminated after losing all four games so far, scoring one goal and conceding seven.
Alexander Bah, Goncalo Guedes and David Neres are out of action, but former Juventus star Angel Di Maria starts in support of Casper Tengstedt.
Familiar faces in the squad to Serie A fans include ex-Fiorentina striker Arthur Cabral and former Inter flop Joao Mario.
These teams met last season in the Champions League quarter-finals and Benfica have never been able to beat Inter, managing just two draws from six games.
Benfica: Trubin; Aursnes, Antonio Silva, Otamendi, Morato; Joao Neves, Florentino; Di Maria, Rafa Silva, Joao Mario; Tengstedt
Benfica bench: Samuel Soares, Kokubo, Cabral, Orkun Kokcu, D Jurasek, Chiquinho, Musa, Victor, Tomas Araujo, Antunes Gouveia
Inter: Audero; Bisseck, De Vrij, Acerbi; Darmian, Frattesi, Asllani, Klaassen, Carlos Augusto; Sanchez, Arnautovic
Inter bench: Sommer, Di Gennaro, Cuadrado, Thuram, Lautaro Martinez, Calhanoglu, Mkhitaryan, Barella, Dimarco, Stabile, Kamate, Stankovic,
Ref: Treimanis (LVA)
Player statistic
João Mário (Assist: Casper Tengstedt) |
7' | |||
João Mário | 13' | |||
João Mário | 34' |
53' | Marko Arnautovic | |||
58' | Davide Frattesi (Assist: Francesco Acerbi) | |||
João Mário | 72' | |||
72' | Alexis Sánchez | |||
76' | Juan Cuadrado | |||
Morato | 78' | |||
António Silva | 86' |