Dusan Vlahovic, Federico Chiesa and Hans Nicolussi Caviglia start for Juventus in the top of the table showdown against Lautaro Martinez, Marcus Thuram and Hakan Calhanoglu’s Inter.
It kicks off at the Allianz Juventus Stadium in Turin at 19.45 GMT.
This is not just a bitter rivalry and the Derby d’Italia, but also second against first, separated at the top by only two points.
A victory would make Juve the new Serie A leaders, while Inter have the opportunity to go five points clear.
The Bianconeri have Vlahovic back in the starting XI with Chiesa, sending Moise Kean and Arkadiusz Milik to the bench, while Locatelli is not ready to start after having to withdraw from international duty with a cracked rib.
Max Allegri pulls a surprise, giving youth team product Nicolussi Caviglia the midfield role, only his second appearance of the season after a two-minute substitute cameo against Cagliari.
Timothy Weah, Danilo and Mattia De Sciglio are still out of action, though Alex Sandro returns from a lengthy lay-off.
Paul Pogba and Nicolò Fagioli are suspended due to off the field issues.
Inter are forced to reshuffle in defence, as Alessandro Bastoni and Benjamin Pavard are out, with ex-Juve man Juan Cuadrado nowhere near fully fit either.
Alexis Sanchez picked up a knock on international duty with Chile, though there was never any doubt that Marcus Thuram would support Lautaro Martinez.
When these sides met last season, Juventus won home and away in Serie A, but were beaten in the tempestuous Coppa Italia semi-final.
Juventus: Szczesny; Gatti, Bremer, Rugani; Cambiaso, McKennie, Nicolussi Caviglia, Rabiot, Kostic; Vlahovic, Chiesa
Inter: Sommer; Darmian, De Vrij, Acerbi; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Lautaro Martinez
Player statistic
| Andrea Cambiaso |  |
11' | ||
| Dusan Vlahovic (Assist: Federico Chiesa) |
 |
27' | ||
| 33' | |
Lautaro Martínez (Assist: Marcus Thuram) |
| 75' | |
Juan Cuadrado | ||
| Filip Kostic | |
79' |
Match statistic
