Samuel Chukwueze, Christian Pulisic and Luka Jovic are set to start in Milan‘s attack against Fiorentina who will rely on Nico Gonzalez and Mbala N’Zola.
It kicks off at 19:45 GMT at San Siro on Saturday and it’s a must-win game for the Rossoneri who are winless in the last four league matches.
Stefano Pioli is short of options in attack as Rafael Leao and Noah Okafor are injured, while Olivier Giroud is suspended. USMNT international Pulisic will start on the left wing while ex-Fiorentina striker Jovic will be the centre forward with 15-year-old Francesco Camarda on the bench.
Simon Kjaer, Ismael Bennacer, Mattia Caldara, Marco Spotiello, Pierre Kalulu and Marco Pellegrino are also injured.
Ruben Loftus-Cheek is available but is expected to start on the bench ahead of next week’s Champions League fixture against Borussia Dortmund.
Fiorentina must cope without the suspended Luca Ranieri plus the injured Gaetano Castrovilli, Dodo and Michael Kayode.
Alfred Duncan is favourite over Rolando Mandragora in central midfield, while Christian Kouamé or Josip Brekalo will get the nod on the left wing.
Milan vs Fiorentina – probable line-ups
Milan (4-3-3): Maignan; Calabria, Thiaw, Tomori, Theo Hernandez; Musah, Reijnders, Pobega; Chukwueze, Jovic, Pulisic.
Fiorentina (4-2-3-1): Terracciano; Parisi, Milenkovic, Martinez Quarta, Biraghi; Arthur, Duncan; Nico Gonzalez, Bonaventura, Kouamè; Nzola.