Lazio and Fiorentina go head-to-head for European places, as Taty Castellanos and Mattia Zaccagni take on Lucas Beltran and Nico Gonzalez.
It kicks off at the Stadio Olimpico at 19.45 GMT.
The last couple of weeks have been mixed for both teams, as Maurizio Sarri’s men went from back-to-back Serie A wins to a heavy 3-0 Champions League defeat away to Feyenoord.
Similarly, the Viola suffered a shock home loss to Empoli on Monday, then thumped Serbians Cukaricki 6-0 in the Conference League.
Nicolò Casale is out with a thigh strain, but Mattia Zaccagni returns and Castellanos is preferred to not fully fit Ciro Immobile upfront.
Fiorentina are down to the bare bones in defence, as Michael Kayode sprained his ankle on Thursday, joining Dodo, Yerry Mina and Gaetano Castrovilli on the treatment table.
Giacomo Bonaventura and Cristiano Biraghi are available after missing the Conference League game, while Beltran starts after finally breaking his duck with a brace midweek.
Fiorentina have not beaten Lazio since May 2021, managing just one draw from four meetings.
Their last away victory was back in May 2016, a 4-2 thriller at the Olimpico.
Lazio: Provedel; Lazzari, Patric, Romagnoli, Marusic; Guendouzi, Rovella, Luis Alberto; Felipe Anderson, Castellanos, Zaccagni
Fiorentina: Terracciano; Parisi, Milenkovic, Martinez Quarta, Biraghi; Arthur, Duncan; Ikone, Bonaventura, Nico Gonzalez; Beltran
Player statistic
| Manuel Lazzari |  |
31' | ||
| 40' | |
Alfred Duncan | ||
| Nicolò Rovella | |
45+2' | ||
| 45+2' | |
Jonathan Ikoné |
| 55' | |
Giacomo Bonaventura | ||
| Mattia Zaccagni | |
66' | ||
| Ciro Immobile |  |
90+5' |
Match statistic
