Milan make changes including Samuel Chukwueze to join Olivier Giroud and Rafael Leao in the Champions League opener against Sandro Tonali’s Newcastle United.
It kicks off at San Siro at 17.45 UK time (16.45 GMT).
The Rossoneri reached the semi-final of the Champions League last season, but confidence is low after Saturday’s 5-1 Derby della Madonnina defeat to rivals Inter.
With that in mind, Stefano Pioli drops Christian Pulisic and Tijjani Reijnders to bring in Samuel Chukwueze and Tommaso Pobega, while Fikayo Tomori returns from suspension in place of Simon Kjaer.
Ismael Bennacer, Pierre Kalulu and Mattia Caldara are out of action.
Fate saw the opening fixture of the group phase bring Tonali back to San Siro just weeks after his move to Tyneside in a deal worth €80m.
Alexander Isak is the striker to watch out for, as the 23-year-old Swede already has two goals in four Premier League games this season.
It has been a mixed start to the campaign for Newcastle, who beat Aston Villa 5-1 in the opening round, then lost three in a row against Manchester City, Liverpool and Roberto De Zerbi’s Brighton.
They got back on track at the weekend with a 1-0 over Brentford, decided by Callum Wilson’s penalty.
It is also a reunion with Sven Botman, who had been on the verge of joining Milan in 2022, while Joelinton and Joe Willock are injured.
Miguel Almiron is dropped in favour of Jacob Murphy on the right wing.
The group is completed by Paris Saint-Germain and Borussia Dortmund.
Milan: Maignan; Calabria, Thiaw, Tomori, Theo Hernandez; Loftus-Cheek, Krunic, Pobega; Chukwueze, Giroud, Leao
Milan bench: Mirante, Sportiello; Bartesaghi, Florenzi, Kjær; Adli, Musah, Pulisic, Reijnders; Jovic, Okafor
Newcastle United: Pope; Trippier, Schar, Botman, Burn; Bruno Guimaraes, Longstaff, Tonali; Murphy, Isak, Gordon
Newcastle bench: Karius, Harris, Dummett, Lascelles, Wilson, Targett, Barnes, Hall, Livramento, Almiron, Anderson, L Miley
Ref: Sanchez (ESP)
Player statistic
| Davide Calabria |  |
41' |
| 49' | |
Fabian Schär | ||
| Yunus Musah | |
82' | ||
| Olivier Giroud | |
83' | ||
| Rade Krunic | |
89' |
Match statistic
