Napoli are without injured Kvicha Kvaratskhelia, so Giacomo Raspadori starts with Victor Osimhen and debutant Jens Cajuste to begin the defence of their title against newly-promoted Frosinone.
It kicks off at the Stadio Benito Stirpe at 17.30 UK time (16.30 GMT).
You can follow all the build-up and action as it happens from this game, Empoli–Verona, Genoa–Fiorentina and Inter-Monza on the LIVEBLOG.
The Partenopei were runaway Scudetto winners last season and a lot has changed, including coach Rudi Garcia and the departure of Kim Min-jae.
Most of the squad remains intact, but Kvaratskhelia is out with a muscular problem, plus Diego Demme is awaiting a transfer back to Germany.
Raspadori is chosen rather than Chucky Lozano to complete the attack with Osimhen and Matteo Politano.
Andre Frank Zambo Anguissa is only considered fit enough for the bench, so Jens Cajuste makes his debut from the start.
Frosinone won the Serie B title last season, but they too changed coach as Fabio Grosso walked away to be replaced by Eusebio Di Francesco.
Former Sassuolo players Riccardo Marchizza and Abdou Harroui form the midfield, while Karlo Lulic and Sergio Kalaj are injured.
In their Serie A history, these teams met four times and Napoli won all of them.
Frosinone: Turati; Oyono, Monterisi, Romagnoli, Marchizza; Harroui, Mazzitelli, Gelli; Baez, Cuni, Caso
Napoli: Meret; Di Lorenzo, Rrahmani, Juan Jesus, Olivera; Cajuste, Lobotka, Zielinski; Politano, Osimhen, Raspadori