Juventus start Federico Chiesa in an intriguing new trident attack with Angel Di Maria and Arkadiusz Milik in the Europa League quarter-final with a Sporting CP side that eliminated Arsenal last time out.
It kicks off at the Allianz Juventus Stadium in Turin at 20.00 UK time (19.00 GMT).
The second leg will be in Lisbon next Thursday and the away goals rule no longer applies, so if the teams are level on aggregate, it goes to extra time.
Alex Sandro and Mattia De Sciglio are on the treatment table, while Dusan Vlahovic and Paul Pogba are only fit for the bench.
The big news is the return of Chiesa from the start after muscular problems, forming an exciting new attack with Di Maria and Milik.
A boost is needed after the Serie A defeat to Lazio at the weekend.
Sporting CP dropped down from the Champions League group phase, as did Juve, and took out one of the favourites when eliminating Arsenal from the Europa League Round of 16 on penalties.
Sporting have never won on Italian soil, managing only three draws and 11 defeats.
Manuel Ugarte is suspended, so Pedro Goncalves steps into midfield, while Francisco Trincao scored a hat-trick at the weekend.
Jovane Cabral, Daniel Braganca and Paulinho are injured.
Juventus: Szczesny; Gatti, Bremer, Danilo; Cuadrado, Locatelli, Rabiot, Kostic; Di Maria, Milik, Chiesa
Sporting CP: Adan; St. Juste, Coates, Goncalo Inacio; Ricardo Esgaio, Pedro Gonçalves, Morita, Chermiti; Francisco Trincao, Edwards, Nuno Santos
Ref: Umut Meler (TUR)
Player statistic
| 20' |  |
Gonçalo Inácio | ||
| Adrien Rabiot | |
24' |
| Dusan Vlahovic | |
65' | ||
| Federico Gatti |  |
73' |
Match statistic
