Inter star Edin Dzeko has recovered from COVID, but Alexis Sanchez is likely to start with Lautaro Martinez in attack, while Maurizio Sarri looks to Ciro Immobile and Pedro.
It kicks off at 19.45 UK time.
Hakan Calhanoglu is suspended and should be replaced by Arturo Vidal. The former Juventus midfielder has contributed to six goals in his career against Lazio (four goals and two assists).
The only game lost by Inter so far is the reverse fixture at the Stadio Olimpico in October. They’ve won six games in a row without conceding for the first time in their history and are unbeaten in 26 games at the Stadio Meazza.
Lazio have only collected 11 points in 10 away matches this season, but have won two of their last three away games from the Stadio Olimpico, against Sampdoria and Venezia.
Mattia Zaccagni is the favourite to start over Felipe Anderson in Lazio’s attacking trident. Sarri is unbeaten in seven league games vs. Inter (5W, 2D) and has the highest winning percentage among coaches who faced Inter at least 10 times.
Inter (3-5-2): Handanovic; Skriniar, De Vrij, Bastoni; Dumfries, Barella, Brozovic, Vidal, Perisic; Lautaro Martinez, Sanchez.
Lazio (4-3-3): Strakosha; Marusic, Luiz Felipe, Radu, Hysaj; Milinkovic-Savic, Cataldi, Luis Alberto; Pedro, Immobile, Zaccagni.