Juventus experiment with their formation, using Gonzalo Higuain and Mario Mandzukic together, for their trip to Palermo.
It kicks off in Sicily at 17.00 UK time (16.00 GMT), follow the build-up and action on our LIVEBLOG.
The Bianconeri crushed Cagliari 4-0 midweek to get back on top of the Serie A table and are preparing for a crucial Champions League trip to Dinamo Zagreb.
Juventus experiment with their formation, using Gonzalo Higuain and Mario Mandzukic together, for their trip to Palermo.
It kicks off in Sicily at 17.00 UK time (16.00 GMT), follow the build-up and action on our LIVEBLOG.
The Bianconeri crushed Cagliari 4-0 midweek to get back on top of the Serie A table and are preparing for a crucial Champions League trip to Dinamo Zagreb.
Medhi Benatia is still on the treatment table with Claudio Marchisio, while Patrice Evra, Giorgio Chiellini and ex-Palermo star Paulo Dybala are rested.
It gives Daniele Rugani his second consecutive start in defence, having also scored his debut goal against Cagliari on Wednesday.
Dani Alves is surprisingly picked for the right flank rather than Stephan Lichtsteiner, who is not on the Champions League squad list.
The biggest change is in attack, where Max Allegri experiments with two centre-forwards, Higuain sharing the limelight with Mandzukic.
Mario Lemina is in the playmaker role, again giving Miralem Pjanic more freedom to roam.
Palermo have had a typically chaotic campaign already, losing Coach Davide Ballardini just two games in, but new boss Roberto De Zerbi has been making a difference.
He lost the opener 3-0 to Napoli, albeit while sitting out a touchline ban, then drew 1-1 with Crotone before earning a surprise 1-0 victory away to Atalanta this week.
Robin Quaison, Aleksandar Trajkovski, Slobodan Rajkovic and Carlos Embalo are absent, but Ilija Nestorovski is rested after scoring two in as many games.
Instead, Hungarian Norbert Balogh is given the starting spot with Alessandro Diamanti and Ivaylo Chochev.
Juve-owned Edoardo Goldaniga is in the three-man defence.
Palermo have lost their last eight meetings with Juventus, home and away, failing to score a single goal and conceding 17.
The most recent win was 2-1 at the Barbera in February 2011.
Palermo: Posavec; Cionek, Gonzalez, Goldaniga; Rispoli, Jajalo, Gazzi, Aleesami; Diamanti, Chochev; Balogh
Palermo bench: Marson, Fulignati, Vitiello, Andelkovic, Hiljemark, Sallai, Bouy, Bruno Henrique, Nestorovski, Pezzella, Lo Faso
Juventus: Buffon; Barzagli, Bonucci, Rugani; Dani Alves, Khedira, Lemina, Pjanic, Alex Sandro; Mandzukic, Higuain
Juventus bench: Neto, Audero, Chiellini, Cuadrado, Hernanes, Pjaca, Dybala, Asamoah, Lichtsteiner, Sturaro, Evra