It’s the Derby della Capitale as Edin Dzeko, Gervinho and Mohamed Salah take on Felipe Anderson, Antonio Candreva and Filip Djordjevic.
It kicks off at the Stadio Olimpico at 14.00 GMT, follow all the action and build-up from today’s Serie A games on our LIVEBLOG.
There is so much more than local pride at stake here, as these sides are also challenging for the top spots.
It’s the Derby della Capitale as Edin Dzeko, Gervinho and Mohamed Salah take on Felipe Anderson, Antonio Candreva and Filip Djordjevic.
It kicks off at the Stadio Olimpico at 14.00 GMT, follow all the action and build-up from today’s Serie A games on our LIVEBLOG.
There is so much more than local pride at stake here, as these sides are also challenging for the top spots.
Roma were beaten by Inter last week and narrowly defeated Bayer Leverkusen 3-2 to keep their Champions League hopes alive, despite throwing away a 2-0 lead.
Lazio have lost two on the trot in Serie A, but a 2-0 victory away to Rosenborg on Thursday revived their spirits.
Miralem Pjanic is a huge loss for the Giallorossi and sits out a ban following his red card against Inter, while Francesco Totti and Kevin Strootman are long-term absentees.
Daniele De Rossi, Alessandro Florenzi and Douglas Maicon all failed late fitness tests.
That means William Vainqueur takes over in central midfield and Rudi Garcia transforms his tactics for a 4-2-3-1 with Iago Falque stepping in.
Lazio only really miss Stefan de Vrij, who will be out for around four to five months after knee surgery, as Marco Parolo returns to the starting XI.
Djordjevic is picked ahead of Miroslav Klose following his brace in the Europa League, flanked by Felipe Anderson and Candreva, while Senad Lulic is in a more advanced midfield role.
There will be a strange atmosphere in the Olimpico, as both Roma and Lazio ultras are boycotting the game over barriers in the Curva Sud and Nord.
That means the ends of the stadium will be largely empty, but groups of supporters are accompanying the teams to the arena from their hotels in moped motorcades.
Roma: Szczesny; Torosidis, Manolas, Rudiger, Digne; Vainqueur, Nainggolan; Salah, Iago Falque, Gervinho; Dzeko
Roma bench: De Sanctis, Lobont, Castan, Maicon, Keita, Gyömbér, Nura, Gyömbér, Machin, Uçan, Florenzi, Emerson Palmieri, Ponce, Iturbe, Sadiq
Lazio: Marchetti; Basta, Mauricio, Gentiletti, Radu; Parolo, Biglia, Lulic; Candreva, Djordjevic, Felipe Anderson
Lazio bench:Berisha, Guerrieri, Konko, Hoedt, Patric, Braafheid, Oikonomidis, Onazi, Morrison, Cataldi, Kishna, Milinkovic-Savic, Mauri, Keita, Matri, Klose