Inter could use Matias Vecino as trequartista rather than Joao Mario in the Derby della Madonnina, while Andre Silva starts for Milan.
It kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
The Nerazzurri are without injured Marcelo Brozovic, who impressed in the role behind striker Mauro Icardi against Benevento last time out, scoring two goals.
He picked up an injury on international duty with Croatia and is out for several weeks.
Inter could use Matias Vecino as trequartista rather than Joao Mario in the Derby della Madonnina, while Andre Silva starts for Milan.
It kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
The Nerazzurri are without injured Marcelo Brozovic, who impressed in the role behind striker Mauro Icardi against Benevento last time out, scoring two goals.
He picked up an injury on international duty with Croatia and is out for several weeks.
Joao Mario had been expected to take over, flanked by Antonio Candreva and Ivan Perisic, but La Gazzetta dello Sport suggests a different tack from Luciano Spalletti.
Former Fiorentina man Vecino could instead be pushed up to that supporting role, leaving Roberto Gagliardini and Borja Valero in midfield.
As for Milan, they are without Nikola Kalinic – who famously scored a hat-trick for Fiorentina against Inter at San Siro – Andrea Conti and Luca Antonelli, plus the suspended Hakan Calhanoglu.
Andre Silva takes over the centre-forward role with support most likely from Suso, a pairing that so far has only been used in the Europa League against Shkendija.
Fabio Borini and Ricardo Rodriguez take the wings of a 3-5-2 system with Lucas Biglia and Franck Kessie in the middle.
Jack Bonaventura may well take the Calhanoglu role of moving between midfield and attack in a versatile almost-trequartista position.
Inter (probable): Handanovic; D'Ambrosio, Skriniar, Miranda, Nagatomo; Gagliardini, Borja Valero; Candreva, Vecino, Perisic; Icardi
Milan (probable): G Donnarumma; Musacchio, Bonucci, Romagnoli; Borini, Kessie, Biglia, Bonaventura, Rodriguez; Suso, Andre Silva