Inter and Lazio face off in a game that could decide both the Scudetto and the Champions League places, as Romelu Lukaku and Marcelo Brozovic take on Ciro Immobile and Sergej Milinkovic-Savic.
It kicks off at the Stadio Meazza at 11.30 UK time (10.30 GMT).
If Lazio fail to win here and Napoli beat Salernitana this afternoon, the Scudetto will mathematically go to the Partenopei.
Atalanta beat Torino last night, while Roma and Milan drew, so the top seven are all crushed together.
It is also potentially crucial in the race for the top four, with the Nerazzurri fresh from booking their place in the Coppa Italia Final after a midweek win over Juventus.
Because of that midweek tie, Lautaro Martinez is rested, with Milan Skriniar injured, so Joaquin Correa and Francesco Acerbi take on their former club.
Lazio welcome back Danilo Cataldi from suspension after the controversial defeat to Torino, with Immobile also fit to start after recovering from a car crash.
Inter: Onana; D’Ambrosio, Acerbi, Bastoni; Darmian, Barella, Brozovic, Mkhitaryan, Dimarco; Lukaku, Correa
Lazio: Provedel; Marusic, Casale, Romagnoli, Hysaj; Milinkovic-Savic, Cataldi, Luis Alberto; Felipe Anderson, Immobile, Zaccagni
Player statistic
20' | Mattia Zaccagni | |||
30' | Felipe Anderson (Assist: Luis Alberto) | |||
Danilo D’Ambrosio | 35' |
Alessandro Bastoni | 62' | |||
Lautaro Martínez (Assist: Romelu Lukaku) |
77' | |||
81' | Adam Marusic | |||
Robin Gosens (Assist: Romelu Lukaku) |
83' | |||
83' | Luis Alberto | |||
Lautaro Martínez | 90' | |||
90+8' | Alessio Romagnoli |