Roma use Pedro, Henrikh Mkhitaryan and Edin Dzeko upfront as they seek their first win of the season against struggling Udinese, who start Roberto Pereyra.
It kicks off at the Dacia Arena at 19.45 UK time (18.45 GMT).
You can follow the build-up and action as it happens on the LIVEBLOG.
Roma use Pedro, Henrikh Mkhitaryan and Edin Dzeko upfront as they seek their first win of the season against struggling Udinese, who start Roberto Pereyra.
It kicks off at the Dacia Arena at 19.45 UK time (18.45 GMT).
You can follow the build-up and action as it happens on the LIVEBLOG.
The Giallorossi have had a chaotic start to the campaign, as their 0-0 draw with Hellas Verona was turned into a 3-0 defeat by default for irregularly fielding Amadou Diawara.
They then fumbled a lead to draw 2-2 with 10-man Juventus, so have just one point from the opening two rounds.
Diego Perotti flew out to Turkey today to complete his Fenerbahce transfer, with Javier Pastore, Rick Karsdorp and Nicolò Zaniolo injured.
Therefore, Pedro Rodriguez and Mkhitaryan again support Dzeko, with Lorenzo Pellegrini in a deeper midfield role, Davide Santon and Leonardo Spinazzola as the wing-backs.
Udinese are doing even worse, having lost both games so far to Verona and 10-man Spezia, above all failing to score a single goal.
That is why there are numerous changes to the line-up, with Roberto Pereyra thrown straight in after his transfer from Watford, Tolgay Arslan and Thomas Ouwejan also summer arrivals.
Rolando Mandragora, Jens Stryger-Larsen, Mato Jajalo and Walace are still unavailable.
Roma have won six of their last seven Serie A trips to Udinese, drawing the other. Last season they emerged 4-0 winners despite Federico Fazio’s red card after just 31 minutes.
Udinese: Musso; Becao, De Maio, Samir; Ter Avest, De Paul, Arslan, Pereyra, Ouwejan; Lasagna, Okaka
Roma: Mirante; Mancini, Ibanez, Kumbulla; Santon, Veretout, Pellegrini, Spinazzola; Pedro, Mkhitaryan; Dzeko
Ref: Abisso