Napoli aim to continue their Europa League march with a difficult trip to Turkey for Trabzonspor.
It kicks off at 18.00 GMT and is the first leg in the Round of 32.
The Partenopei had started this season in the Champions League preliminary round, but lost to Athletic Bilbao and have been targeting final success ever since.
Rafa Benitez has a lot of history in this tournament and they won the group phasr thanks to four wins one draw and one defeat, in which they conceded only three goals and scored 11.
Napoli aim to continue their Europa League march with a difficult trip to Turkey for Trabzonspor.
It kicks off at 18.00 GMT and is the first leg in the Round of 32.
The Partenopei had started this season in the Champions League preliminary round, but lost to Athletic Bilbao and have been targeting final success ever since.
Rafa Benitez has a lot of history in this tournament and they won the group phasr thanks to four wins one draw and one defeat, in which they conceded only three goals and scored 11.
Lorenzo Insigne, Michu and Juan Camilo Zuniga are still out of action, but Marek Hamsik is dropped in favour of Manolo Gabbiadini, Jonathan de Guzman and Dries Mertens.
Mariano Andujar takes over in goal from error-prone Rafael, while Paulo Henrique gets a rare start.
Trabzonspor have injury problems, missing ex-Milan full-back Kevin Constant as well as Mehmet Ekici, Onir Kivrak, Mustapha Yutabare, Essaid Belkalem and Majeed Waris.
The reassuring news for Napoli is that Trabzonspor have never won a UEFA match in the spring, losing both legs against Juventus and PSV Eindhoven.
It is raining heavily in Turkey this evening and that could affect the performances.
Trabzonspor: Hakan Arikan; Bosingwa, Aykut Demir, Medjani, Ishak Dogan; Sefa Yilmaz, Ozer Hurmaci, Fatih Atik, Erkan Zengin, Soner Aydogdu; Oscar Cardozo
Trabzonspor bench: Ibrahim Demir, Salih Dursun, Zeki Yavru, Musa Nizam
Napoli: Andujar; Henrique, Albiol, Koulibaly, Ghoulam; Inler, Gargano; Gabbiadini, De Guzman, Mertens; Higuain
Napoli bench: Rafael, Britos, Maggio, Hamsik, David Lopez, Callejon, Duvan Zapata