Inter visit high-flying SPAL with Keita Balde Diao supporting Mauro Icardi and Borja Valero stepping into midfield.
It kicks off at 19.30 UK time (18.30 GMT) at the Stadio Paolo Mazza in Ferrara.
Follow the build-up and action as it happens on the LIVEBLOG.
The Nerazzurri are seeking a sixth consecutive victory between Serie A and the Champions League.
Inter visit high-flying SPAL with Keita Balde Diao supporting Mauro Icardi and Borja Valero stepping into midfield.
It kicks off at 19.30 UK time (18.30 GMT) at the Stadio Paolo Mazza in Ferrara.
Follow the build-up and action as it happens on the LIVEBLOG.
The Nerazzurri are seeking a sixth consecutive victory between Serie A and the Champions League.
Marcelo Brozovic is out injured, with Matteo Politano and Antonio Candreva rested in favour of Keita Balde Diao as part of the supporting trio.
The others are, as usual, Radja Nainggolan and Ivan Perisic, while Borja Valero steps in to midfield.
Sime Vrsaljko returns from injury at right-back, while Stefan de Vrij is rested.
SPAL had been the surprise outfit of the season in the opening month, but have now lost three on the bounce.
Jasmin Kurtic, Federico Viviani and Lorenzo Simic are injured, taking away a lot of their creativity and verve in midfield.
Mirko Antenucci is partnered by Andrea Petagna, with Alberto Paloschi on the bench, while it looks as if Leonardo Semplici has adapted his 3-5-2 to a 4-4-2.
SPAL: Gomis; Cionek, Djourou, Felipe, Fares; Lazzari, Valoti, Schiattarella, Missiroli; Antenucci, Petagna
SPAL bench: Thiam, Milinkovic-Savic, Floccari, Moncini, Bonifazi, Valdifiori, Vicari, Dickmann, Everton Luiz, Costa, Paloschi, Vitale
Inter: Handanovic; Vrsaljko, Skriniar, Miranda, Asamoah; Vecino, Borja Valero; Keita, Nainggolan, Perisic; Icardi
Inter bench: Padelli, Gagliardini, De Vrij, Lautaro Martinez, Ranocchia, Joao Mario, Politano, Dalbert, D’Ambrosio, Candreva
Ref: Maresca