Inter start Xherdan Shaqiri, Lukas Podolski and a completely revamped defence against Sassuolo.
It kicks off at the Mapei Stadium at 11.30 GMT, click here for a match preview.
Roberto Mancini is under pressure after results took a turn for the worse, picking up one point from the last two Serie A rounds.
The home defeat to Torino was a big shock and it remains to be seen how they will shake off that loss.
Inter start Xherdan Shaqiri, Lukas Podolski and a completely revamped defence against Sassuolo.
It kicks off at the Mapei Stadium at 11.30 GMT, click here for a match preview.
Roberto Mancini is under pressure after results took a turn for the worse, picking up one point from the last two Serie A rounds.
The home defeat to Torino was a big shock and it remains to be seen how they will shake off that loss.
Juan Jesus and Danilo D’Ambrosio are suspended, while Yuto Nagatomo, Marco Andreolli, Hugo Campagnaro and Jonathan are sidelined.
Mancio starts January signings Shaqiri and Podolski together with Mateo Kovacic and Rodrigo Palacio, resting Mauro Icardi.
The defence has to be completely revamped with Dodo and youth team player Donkor.
Sassuolo famously lost this fixture 7-0 during their debut Serie A campaign and earlier this season were beaten 7-0 at San Siro too.
As always, they look to star strikers Simone Zaza and Domenico Berardi to inspire the 4-3-3 formation.
Francesco Acerbi and Antonio Floro Flores sit out bans with Gianluca Pegolo, Federico Peluso and Saphir Taider, who is at the African Cup of Nations.
Sassuolo: Consigli; Vrsaljko, Terranova, Cannavaro, Longhi; Biondini, Magnanelli, Missiroli; Berardi, Zaza, Sansone
Sassuolo bench: Pomini, Polito; Bianco, Antei, Gazzola, Brighi, Chibsah, Lodesani, Sereni, Floccari
Inter: Handanovic; Donkor, Ranocchia, Vidic, Dodò; Guarin, Medel; Kovacic, Palacio, Shaqiri; Podolski
Inter bench: Carrizo, Berni; Sciacca, Obi, Dimarco, Kuzmanovic, Hernanes, Brozovic, Puscas, Bonazzoli, Icardi