Inter need to build on Champions League success with Mauro Icardi and Radja Nainggolan, but Sampdoria are on splendid form at Marassi.
It kicks off at 19.30 UK time (18.30 GMT), follow the build-up and action as it happens on the LIVEBLOG.
The ‘Pazza Inter’ nickname is proving very apt at the moment, as the Nerazzurri are completely unpredictable, even during the same match.
Inter need to build on Champions League success with Mauro Icardi and Radja Nainggolan, but Sampdoria are on splendid form at Marassi.
It kicks off at 19.30 UK time (18.30 GMT), follow the build-up and action as it happens on the LIVEBLOG.
The ‘Pazza Inter’ nickname is proving very apt at the moment, as the Nerazzurri are completely unpredictable, even during the same match.
Scudetto contenders pre-season, they’ve already lost to Sassuolo and Parma, while drawing 2-2 with Torino.
They were also trailing at home to Tottenham Hotspur in the Champions League, but fought back for a dramatic 2-1 victory thanks to Icardi’s volley and a Matias Vecino header.
Icardi is yet to break his Serie A duck this season and is hoping to do it against his former club, supported by Nainggolan, Antonio Candreva on the left and Matteo Politano taking the right flank, as Ivan Perisic is rested.
With Sime Vrsaljko injured, Kwadwo Asamoah moves to left-back.
With 11 goals and one assist in 10 games, Sampdoria are Icardi’s favourite victim. The Argentinian scored four in less than 30 minutes against his former club in Inter’s impressive 5-0 win in Genoa last season.
Sampdoria have impressed this term, thrashing Carlo Ancelotti’s Napoli 3-0 and securing a 5-0 victory away to Frosinone.
They also played midweek, as on Wednesday they drew 1-1 with Fiorentina in a rescheduled Week 1 match.
Riccardo Saponara and Vasco Regini are out of action, with Gianluca Caprari and Dawid Kownacki not even on the bench due to muscular issues.
Gaston Ramirez starts behind Fabio Quagliarella and Gregoire Defrel.
Sampdoria: Audero; Bereszynski, Tonelli, Andersen, Murru; Linetty, Ekdal, Praet; Ramirez; Quagliarella, Defrel
Sampdoria bench: Belec, Rafael, Vieira, Sala, Barreto, Jankto, Colley, Leverbe, Tavares, Ferrari, Stijepovic, Rolando
Inter: Handanovic; D’Ambrosio, Skriniar, Miranda, Asamoah; Vecino, Brozovic; Politano, Nainggolan, Candreva; Icardi
Inter bench: Padelli, Gagliardini, De Vrij, Lautaro Martinez, Keita, Ranocchia, Joao Mario, Borja Valero, Dalbert, Perisic