Roma are forced to revamp tactically and in personnel, but a victory over Benevento would take them into the top four.
It kicks off at 19.45 GMT, follow the build-up and action as it happens while giving your views on the LIVEBLOG.
The Giallorossi ended their drought with a hard-fought 1-0 win away to Hellas Verona last weekend, a Cengiz Under strike in the opening minute proving decisive.
Roma are forced to revamp tactically and in personnel, but a victory over Benevento would take them into the top four.
It kicks off at 19.45 GMT, follow the build-up and action as it happens while giving your views on the LIVEBLOG.
The Giallorossi ended their drought with a hard-fought 1-0 win away to Hellas Verona last weekend, a Cengiz Under strike in the opening minute proving decisive.
The young Turkish talent starts again in a 4-2-3-1 formation, with Diego Perotti stepping in to replace suspended Radja Nainggolan.
Stephan El Shaarawy also supports lone centre-forward Edin Dzeko.
Both Nainggolan and Lorenzo Pellegrini sit out bans, while Maxime Gonalons, Rick Karsdorp and January buy Jonathan Silva are injured.
Daniele De Rossi is not 100 per cent fit, so Gerson simply has to partner Kevin Strootman in midfield.
Bruno Peres is frozen out for this weekend and fined after crashing his car and failing a breathalyser test.
Benevento are propping up the table, but have been transformed in the January transfer window, bringing in the likes of former Tottenham Hotspur midfielder Sandro, ex-Arsenal defender Bacary Sagna and Brazilian Guilherme.
Sagna is on the bench for the first time, though Danilo Cataldi and Luca Antei are injured.
Captain Fabio Lucioni continues to sit out his ban for failing a doping test.
Guilherme does start and he’ll be particularly eager to score so he can dedicate the goal to his son Enzo, who was born yesterday. So will former Roma youth product Marco D'Alessandro.
Eusebio Di Francesco has faced Benevento three times in his managerial career, losing twice (for Virtus Lanciano in the 2008-09 Serie C campaign) and winning 4-0 earlier this season.
Roma: Alisson; Florenzi, Manolas, Fazio, Kolarov; Strootman, Gerson; Cengiz Under, Perotti, El Shaarawy; Dzeko
Roma bench: Skorupski, Lobont, Juan Jesus, Bouah, De Rossi, Capradossi, Riccardi, Marcucci, Defrel, Schick
Benevento: Puggioni; Letizia, Djimsiti, Costa, Venuti; Viola, Sandro; Djuricic, Guilherme, D’Alessandro; Brignola
Benevento bench: Brignoli, Gyamfi, Sagna, Tosca, Billong, Del Pinto, Memushaj, Iemmello, Diabaté, Lombardi, Parigini, Coda
Ref: Manganiello