Roma are forced to revamp with Edin Dzeko, Diego Perotti and Stephan El Shaarawy against Cristiano Ronaldo’s Real Madrid.
It kicks off at 19.45 GMT, follow the build-up and action as it happens while giving your views on our LIVEBLOG.
The first leg ended 2-0 for the Merengues, though Alessandro Florenzi was denied a clear penalty.
Roma are forced to revamp with Edin Dzeko, Diego Perotti and Stephan El Shaarawy against Cristiano Ronaldo’s Real Madrid.
It kicks off at 19.45 GMT, follow the build-up and action as it happens while giving your views on our LIVEBLOG.
The first leg ended 2-0 for the Merengues, though Alessandro Florenzi was denied a clear penalty.
Luciano Spalletti comes into this trip off the back of seven consecutive Serie A victories, but has some huge line-up problems to deal with.
Daniele De Rossi, Radja Nainggolan and Antonio Rudiger are all injured, so he adjusts to the midfield shortage with a new 4-2-3-1 system.
Perotti, Mohamed Salah and El Shaarawy fan out behind centre-forward Dzeko, who had been dropped for the last two games.
January signing Ervin Zukanovic steps into central defence, as Rudiger is out for at least two weeks with a thigh strain.
Real Madrid’s form has been shaky domestically, though they hit back with a vengeance at the weekend when beating Celta Vigo 7-1.
Cristiano Ronaldo scored four goals to silence jeers from the crowd, as he irritated fans and teammates when claiming “if the rest were playing on my level, we’d be top of the table.”
Karim Benzema is out injured, but Pepe and Gareth Bale return after missing the first leg.
It was reported this week Bale was trying to protect his delicate muscles from a relapse by not driving his car and eating a large quantity of tomatoes.
Dani Carvajal is dropped in favour of Danilo at right-back.
Keylor Navas hasn’t conceded in 630 minutes of football. He’s just 28 minutes away from beating Edwin van der Saar’s Champions League unbeaten record, set in 1995-96 for Ajax.
Real Madrid have not been able to knock an Italian side out in the elimination stages for almost 29 years!
Since September 30 1987, beating Napoli 3-1 on aggregate, they had eight attempts and were always eliminated.
Real Madrid: Keylor Navas; Danilo, Pepe, Sergio Ramos, Marcelo; Modric, Casemiro, Kroos; James Rodriguez, Bale, Cristiano Ronaldo
Real Madrid bench: Kiko Casilla, Varane, Carvajal, Isco, Kovacic, Jesé, Lucas Vazquez
Roma: Szczesny; Florenzi, Manolas, Zukanovic, Digne; Keita, Pjanic; Salah, Perotti, El Shaarawy; Dzeko
Roma bench: De Sanctis, Castan, Maicon, Vainqueur, Torosidis, Totti, Iago Falque