Napoli have Dries Mertens back in the starting XI against a Fiorentina side in fine form with Giovanni Simeone and Federico Chiesa.
It kicks off at the Stadio San Paolo at 17.00 UK time (16.00 GMT), follow the build-up and action as it happens on the LIVEBLOG.
Carlo Ancelotti has no time to lose, because Napoli are already losing touch with the top spots after a crushing 3-0 defeat to Sampdoria.
Napoli have Dries Mertens back in the starting XI against a Fiorentina side in fine form with Giovanni Simeone and Federico Chiesa.
It kicks off at the Stadio San Paolo at 17.00 UK time (16.00 GMT), follow the build-up and action as it happens on the LIVEBLOG.
Carlo Ancelotti has no time to lose, because Napoli are already losing touch with the top spots after a crushing 3-0 defeat to Sampdoria.
The Coach rotated his squad heavily for that game, but is focusing on the old guard here with Jose Callejon and Marek Hamsik back in the starting XI.
However, Mertens gets his first start of the season in place of Arkadiusz Milik, accompanied by Lorenzo Insigne, with Piotr Zielinski providing support from midfield.
There are big changes at the back, with Nikola Maksimovic allowing Raul Albiol to rest and Orestis Karnezis in goal rather than David Ospina.
Fiorentina won both games this season and demolished Chievo 6-1, so their confidence is flying high under Stefano Pioli.
The sons of great Serie A 1990s stars Diego Simeone and Enrico Chiesa have formed a very strong partnership in attack, with Federico Chiesa in particular targeted by Napoli in the summer for a transfer.
Goalkeeper Alban Lafont is injured, so 21-year-old Polish talent Bartlomiej Dragowski takes the gloves.
Jordan Veretout is available after his two-match ban in midfield, as Edimilson makes way.
Napoli: Karnezis; Hysaj, Koulibaly, Maksimovic, Mario Rui; Allan, Hamsik, Zielinski; Callejon, Mertens, Insigne
Napoli bench: Ospina, D'Andrea, Malcuit, Ruiz, Verdi, Ounas, Luperto, Rog, Albiol, Diawara, Milik
Fiorentina: Dragowski; Milenkovic, Pezzella, Vitor Hugo, Biraghi; Benassi, Veretout, Gerson; Chiesa, Simeone, Eysseric
Fiorentina bench: Ghidotti, Laurini, Ceccherini, Norgaard, Pjaca, Mirallas, Dabo, Hancko, Sottil, Edimilson, Diks, Thereau