Both Milan and Juventus are forced to make radical changes due to injuries, bans and COVID, as Davide Calabria moves into midfield against Paulo Dybala and Cristiano Ronaldo.
It kicks off at San Siro at 19.45 GMT, you can follow all the build-up and action as it happens on the LIVEBLOG.
This is a huge match between the current Serie A leaders and the side that won the last nine Scudetto titles.
Both Milan and Juventus are forced to make radical changes due to injuries, bans and COVID, as Davide Calabria moves into midfield against Paulo Dybala and Cristiano Ronaldo.
It kicks off at San Siro at 19.45 GMT, you can follow all the build-up and action as it happens on the LIVEBLOG.
This is a huge match between the current Serie A leaders and the side that won the last nine Scudetto titles.
Unfortunately, it won’t be a full-strength squad for either coach, as they have an extraordinary number of problems, some of them arising over the last 24 hours.
Juventus knew they were in trouble with Alvaro Morata injured, Alex Sandro and Juan Cuadrado testing positive for COVID-19.
Dybala also had a fever over the last couple of days, but he is fit to start upfront, with Gianluca Frabotta coming in to the versatile wide role.
Milan knew they would have to do without suspended Sandro Tonali and long-term injury absentees Zlatan Ibrahimovic, Ismael Bennacer, Alexis Saelemaekers and Matteo Gabbia.
However, this morning, it was confirmed Ante Rebic and Rade Krunic had both tested positive for COVID-19.
This left Stefano Pioli with practically no midfielders other than Franck Kessie, so Davide Calabria had to be pushed up into a more advanced role, with Diogo Dalot at right-back.
Theo Hernandez returned from suspension, having missed the 2-0 win away to Benevento on Sunday.
There were few real options upfront either, so Rafael Leao was again the centre-forward, with Samu Castillejo and Jens Petter Hauge joining Hakan Calhanoglu.
Milan: G Donnarumma; Dalot, Kjaer, Romagnoli, Theo Hernandez; Calabria, Kessie; Castillejo, Calhanoglu, Hauge, Leao
Milan bench: Tatarusanu, Conti, Duarte, Kalulu, Musacchio, Brahim Diaz, Frigerio, Colombo, Maldini
Juventus: Szczesny; Danilo, De Ligt, Bonucci, Frabotta; Chiesa, Bentancur, Rabiot, Ramsey; Dybala, Ronaldo
Juventus bench: Buffon, Pinsoglio, Demiral, Chiellini, Arthur, McKennie, Di Pardo, Portanova, Fagioli, Kulusevski, Bernardeschi, Da Graca
Ref: Irrati