Juventus use Paulo Dybala, Gonzalo Higuain and Federico Bernardeschi together in the trip to Lecce, who start Diego Farias and Khouma Babacar.
It kicks off at the Stadio Via del Mare at 14.00 UK time (13.00 GMT).
You can read all the build-up and action as it happens from this game, Inter-Parma and Genoa-Brescia on the LIVEBLOG.
Juventus use Paulo Dybala, Gonzalo Higuain and Federico Bernardeschi together in the trip to Lecce, who start Diego Farias and Khouma Babacar.
It kicks off at the Stadio Via del Mare at 14.00 UK time (13.00 GMT).
You can read all the build-up and action as it happens from this game, Inter-Parma and Genoa-Brescia on the LIVEBLOG.
Maurizio Sarri’s Bianconeri are resting Cristiano Ronaldo, who has been left in Turin along with injured Aaron Ramsey, Douglas Costa, Marko Pjaca and Giorgio Chiellini.
Despite a midweek round coming up against Genoa, Matthijs de Ligt and Leonardo Bonucci retain their places without rest, but Danilo returns after a muscular injury at right-back.
There are changes in midfield, with Emre Can and Rodrigo Bentancur partnering Miralem Pjanic.
It’s a new front three with Bernardeschi supporting Argentines Dybala – fresh from his brace to beat Lokomotiv Moscow in the Champions League – and Higuain.
Lecce have picked up all seven Serie A points away from home this season, including last week’s 2-2 draw at Milan.
Marco Calderoni scored that last-gasp screamer to equalise at San Siro and he again starts at left-back, hoping to add to his two goals this season.
Marco Mancosu is the trequartista behind Babacar and Farias, who is preferred to Filippo Falco.
Lecce coach Fabio Liverani is in the stands, as he was given a one-match touchline ban for dissent against Milan.
Juventus have a surprisingly poor record in Lecce, losing three of their total 15 Serie A visits, drawing three and winning nine.
Lecce: Gabriel; Meccariello, Lucioni, Rossettini, Calderoni; Petriccione, Tachtsidis, Majer; Mancosu; Farias, Babacar
Lecce bench: Vigorito, Riccardi, Vera, Benzar, Lapadula, Falco, Shakhov, La Mantia, Tabanelli, Rispoli, Lo Faso, Dell’Orco
Juventus: Szczesny; Danilo, Bonucci, De Ligt, Alex Sandro; Emre Can, Pjanic, Bentancur; Bernardeschi; Dybala, Higuain
Juventus bench: Pinsoglio, Buffon, De Sciglio, Khedira, Matuidi, Cuadrado, Rugani, Rabiot, Demiral, Kwang-Son Han
Ref: Valeri