Juventus start Paulo Dybala, Mario Mandzukic and Paul Pogba against Manchester City’s Sergio Aguero and Kevin De Bruyne.
It kicks off in Turin at 19.45 GMT, follow all the build-up and action as it happens on our LIVEBLOG.
City have already qualified for the Last 16 of the Champions League and the Bianconeri will join them with a positive result this evening.
Juventus start Paulo Dybala, Mario Mandzukic and Paul Pogba against Manchester City’s Sergio Aguero and Kevin De Bruyne.
It kicks off in Turin at 19.45 GMT, follow all the build-up and action as it happens on our LIVEBLOG.
City have already qualified for the Last 16 of the Champions League and the Bianconeri will join them with a positive result this evening.
It’s also a head-to-head for top spot in the group, which would in theory lead to an easier draw for the knockouts.
Max Allegri must do without Sami Khedira, Martin Caceres, Roberto Pereyra, Hernanes and Kwadwo Asamoah.
Patrice Evra has recovered from an ankle sprain in the 1-0 win over Milan, but Alex Sandro is preferred on the left of a 3-5-2 system.
The Coach makes some very surprising decisions, dropping Juan Cuadrado and Champions League top scorer Alvaro Morata to the bench.
Instead, Stephan Lichtsteiner takes the right flank and Mandzukic partners Dybala.
Stefano Sturaro fills the gaps with Claudio Marchisio and Paul Pogba in midfield.
Manchester City are fresh from a 4-1 Premier League hammering from Liverpool and will be eager to prove a point.
There are big injury problems ruling out Vincent Kompany, Samir Nasri, Pablo Zabaleta, David Silva, Wilfried Bony and Eliaquim Mangala.
Aguero is back after his six-week lay-off and was already on target this weekend.
He is supported by Kevin De Bruyne, Yaya Toure and Jesus Navas.
Juventus: Buffon; Barzagli, Bonucci, Chiellini; Lichtsteiner, Sturaro, Marchisio, Pogba, Alex Sandro; Mandzukic, Dybala
Juventus bench: Neto, Rugani, Evra, Lemina, Cuadrado, Zaza, Morata
Manchester City: Hart; Sagna, Demichelis, Otamendi, Clichy; Fernando, Fernandinho; Navas, Toure, De Bruyne; Aguero
Manchester City bench: Caballero, Maffeo, Adarabioyo, Kolarov, Delph, Celina, Sterling