Fiorentina are forced to do without Federico Chiesa or Franck Ribery, so Kevin-Prince Boateng and Dusan Vlahovic face Roma’s Edin Dzeko and Chris Smalling.
It kicks off at 19.45 GMT, you can follow all the build-up and action as it happens on the LIVEBLOG.
The Viola narrowly avoided a fifth straight defeat last week, with Vlahovic coming off the bench to fire in a stoppage-time equaliser with Inter.
Fiorentina are forced to do without Federico Chiesa or Franck Ribery, so Kevin-Prince Boateng and Dusan Vlahovic face Roma’s Edin Dzeko and Chris Smalling.
It kicks off at 19.45 GMT, you can follow all the build-up and action as it happens on the LIVEBLOG.
The Viola narrowly avoided a fifth straight defeat last week, with Vlahovic coming off the bench to fire in a stoppage-time equaliser with Inter.
That kept Vincenzo Montella on the bench for now, but a setback here could still see the former Roma player and coach sacked.
He is forced to completely reshuffle his pack, because Chiesa has an ankle injury and has joined Ribery in the stands.
Boateng and Vlahovic are therefore the only real choices upfront.
Milan Badelj passes a fitness test to start in midfield with Gaetano Castrovilli and Erick Pulgar.
Roma are still missing Javier Pastore, Davide Santon, Bryan Cristante, Antonio Mirante and Davide Zappacosta.
Chris Smalling and Justin Kluivert are available again, although only the defender goes into the starting XI for Paulo Fonseca.
Nicolò Zaniolo, Lorenzo Pellegrini and Diego Perotti again fan out behind Edin Dzeko.
It’s a special return to the Stadio Franchi for ex-Fiorentina midfielder Jordan Veretout.
Last season, Roma famously lost a Coppa Italia quarter-final here 7-1 in January, but both their Serie A meetings ended in stalemates.
They haven’t played three consecutive Serie a draws since 1977.
Fiorentina: Dragowski; Milenkovic, Pezzella, Caceres; Lirola, Badelj, Pulgar, Castrovilli, Dalbert; Boateng, Vlahovic
Roma: Pau Lopez; Florenzi, Mancini, Smalling, Kolarov; Veretout, Diawara; Zaniolo, Pellegrini, Perotti; Dzeko
Ref: Orsato