Lazio rest Ciro Immobile, but start Sergej Milinkovic-Savic and Joaquin Correa in the Europa League trip to Scottish champions Celtic.
It kicks off at Celtic Park in Glasgow at 20.00 UK time (19.00 GMT).
You can follow all the build-up and action as it happens from this game and Roma-Borussia Monchengladbach on the LIVEBLOG.
Lazio rest Ciro Immobile, but start Sergej Milinkovic-Savic and Joaquin Correa in the Europa League trip to Scottish champions Celtic.
It kicks off at Celtic Park in Glasgow at 20.00 UK time (19.00 GMT).
You can follow all the build-up and action as it happens from this game and Roma-Borussia Monchengladbach on the LIVEBLOG.
Simone Inzaghi’s men lost the opener at Cluj, having initially taken the lead, then beat Rennes at the Olimpico.
Celtic had a stronger start, having dropped into this tournament out of the Champions League preliminary rounds, as they defeated Cluj and picked up a 1-1 draw away to Rennes.
Thomas Strakosha starts in goal despite an elbow issue, but Luis Alberto and Ciro Immobile are rested, with Adam Marusic suspended.
Milinkovic-Savic is therefore the star man in midfield with Lucas Leiva and Marco Parolo, while Tucu Correa and Felipe Caicedo lead the attack.
Celtic again miss ex-Genoa midfielder Olivier Ntcham with an ankle problem and Jeremie Frimpong is not in the UEFA list, but Ryan Christie returns after sitting out a domestic ban.
Mohamed Elyounoussi and Odsonne Edouard lead the front line.
Celtic: Forster; Elhamed, Ajer, Jullien, Bolingoli-Mbombo; Forrest, Brown, C McGregor; Christie, Edouard, Elyounoussi
Celtic bench: Gordon, Bitton, Bayo, Sinclair, Bauer, Hayes, Rogic
Lazio: Strakosha; Bastos, Vavro, Acerbi; Lazzari, Parolo, Leiva, Milinkovic-Savic, Jony; Caicedo, Correa
Lazio bench: Guerrieri, Luis Felipe, Patric, Berisha, Immobile, Lulic, Cataldi
Ref: Bebek (CRO)