Edin Dzeko returns to the starting XI with Diego Perotti, Stephan El Shaarawy and Mohamed Salah as Roma host Carpi.
It kicks off at 19.45 GMT, follow all the action as it happens and give your views on our LIVEBLOG.
The Giallorossi have won three on the trot and this is their final test before hosting Real Madrid in the Champions League on Wednesday – which is why this game is being played on a Friday night.
Edin Dzeko returns to the starting XI with Diego Perotti, Stephan El Shaarawy and Mohamed Salah as Roma host Carpi.
It kicks off at 19.45 GMT, follow all the action as it happens and give your views on our LIVEBLOG.
The Giallorossi have won three on the trot and this is their final test before hosting Real Madrid in the Champions League on Wednesday – which is why this game is being played on a Friday night.
Luciano Spalletti has transformed the side, aided also by some big January signings, and hopes to keep up that momentum at the Stadio Braglia in Modena.
Dzeko returns to the starting XI following his injury lay-off and is supported by on-form El Shaarawy, Perotti and Salah.
Radja Nainggolan is also back after his ban, but Daniele De Rossi, Francesco Totti, Vasilis Torosidis, Norbert Gyomber and Kevin Strootman are sidelined.
Miralem Pjanic and Seydou Keita are rested for Real Madrid, so William Vainqueur gets a rare start and the four-man defence returns with Alessandro Florenzi at right-back.
Carpi have lost their last two, but were both extremely tight games against Fiorentina and Napoli, beaten only by a last-gasp Mauro Zarate stunner and Gonzalo Higuain penalty.
Other than those outings, the minnows were unbeaten in 2016 and held Inter to a 1-1 draw at San Siro.
Paolo Bianco is suspended, joining Lorenzo Pasciuti, Jonathan De Guzman and Matteo Fedele on the treatment table.
Carpi: Belec; Suagher, Romagnoli, Gagliolo; Sabelli, Crimi, Cofie, Lollo, Letizia; Mancosu, Mbakogu
Carpi bench: Brkic, Colombi, Zaccardo, Daprelà, Porcari, Gnahoré, Verdi, Di Gaudio, Martinho, Lasagna
Roma: Szczesny; Florenzi, Rudiger, Manolas, Digne; Vainqueur, Nainggolan; Salah, Perotti, El Shaarawy; Dzeko
Roma bench: De Sanctis, Lobont, Castan, Maicon, Nura, Zukanovic, Emerson, Keita, Pjanic, Uçan, Sadiq, Iago Falque
Ref: Tagliavento