Roma must recover from the Champions League shock, but visit a Cagliari side that means business on its return to the top flight.
It kicks off at the Stadio Sant’Elia at 19.45 UK time (18.45 GMT), follow the action from all tonight’s Serie A games on the LIVEBLOG.
The Giallorossi’s European ambitions crumbled on Tuesday night with a 3-0 home defeat to Porto in the Champions League play-off.
Roma must recover from the Champions League shock, but visit a Cagliari side that means business on its return to the top flight.
It kicks off at the Stadio Sant’Elia at 19.45 UK time (18.45 GMT), follow the action from all tonight’s Serie A games on the LIVEBLOG.
The Giallorossi’s European ambitions crumbled on Tuesday night with a 3-0 home defeat to Porto in the Champions League play-off.
Daniele De Rossi and Emerson Palmieri were sent off for horror tackles and the side simply fell apart, so how will Luciano Spalletti pick up the pieces?
He visits Sardinia without injured Francesco Totti, Juan Jesus, Vasilis Torosidis, Mario Rui and Antonio Rudiger.
Alessandro Florenzi returns from a spell on the treatment table, while Edin Dzeko is benched in favour of Diego Perotti as a False 9.
He has support from Stephan El Shaarawy, old boy Radja Nainggolan and Mohamed Salah.
Thomas Vermaelen was sent off on his Giallorossi debut and is taking a while to adjust.
Cagliari were promoted top of Serie B last season and reinforced with the likes of Marco Borriello – who scored five goals in his first two competitive appearances – Mauricio Isla, Simone Padoin, Artur Ionita and Portugal’s Euro 2016-winning defender Bruno Alves.
The Sardinians had been leading away to Genoa last week before a flurry of late goals saw them fall 3-1.
Cagliari: Storari; Isla, Ceppitelli, Bruno Alves, Murru; Padoin, Di Gennaro, Ionita; Barella; Borriello, Sau
Roma: Szczesny; Florenzi, Manolas, Vermaelen, Bruno Peres; Strootman, De Rossi, Nainggolan; Salah, Perotti, El Shaarawy