Juventus are expected to unveil their star trio of Gonzalo Higuain, Paulo Dybala and Miralem Pjanic for the first time against Sassuolo.
It kicks off at 17.00 UK time (16.00 GMT), click here for a match preview.
Pjanic is yet to be given his competitive debut in a Bianconeri jersey, having sustained an injury in pre-season.
He played the full 90 minutes for Bosnia in a 2018 World Cup qualifier on Tuesday, beating Estonia 5-0.
Juventus are expected to unveil their star trio of Gonzalo Higuain, Paulo Dybala and Miralem Pjanic for the first time against Sassuolo.
It kicks off at 17.00 UK time (16.00 GMT), click here for a match preview.
Pjanic is yet to be given his competitive debut in a Bianconeri jersey, having sustained an injury in pre-season.
He played the full 90 minutes for Bosnia in a 2018 World Cup qualifier on Tuesday, beating Estonia 5-0.
The former Roma midfielder is set to take the reins in midfield, though it’s reported he’ll be given more freedom to roam than Andrea Pirlo was in that role.
Another big change is in attack, where Higuain and Dybala will start together for the first time.
The Argentines were already friends before Pipita moved to Turin and are eager to create a new partnership on the pitch too.
It’ll be the first time in 21 Serie A games that Mario Mandzukic has not been in the starting XI.
Max Allegri already confirmed Stephan Lichtsteiner will start on the right, as Dani Alves and Juan Cuadrado only returned from international duty in South America yesterday.
Andrea Barzagli could be rested in favour of Medhi Benatia.
Sassuolo have numerous problems, as Domenico Berardi and Gregoire Defrel haven’t even made the trip to Turin due to injury.
Stefano Sensi and Emanuele Terranova are also absent for Eusebio Di Francesco, so ex-Juventus striker Alessandro Matri will inevitably lead the trident attack.
He’s expected to be flanked by Matteo Politano and Antonino Ragusa.
Unlike the last game against Pescara, Ragusa has been correctly registered, so Sassuolo would not risk another 3-0 defeat imposed by the Disciplinary Commission.
The Neroverdi won their opening two Serie A games on the field, but the 2-1 victory over Pescara was revoked because Ragusa was fielded without being correctly registered.
Juventus (probable): Buffon; Benatia, Bonucci, Chiellini; Lichtsteiner, Khedira, Pjanic, Asamoah, Alex Sandro; Dybala, Higuain
Sassuolo (probable): Consigli; Gazzola, Cannavaro, Acerbi, Peluso; Missiroli, Magnanelli, Duncan; Politano, Matri, Ragusa