Angel Di Maria supports Dusan Vlahovic, while Edin Dzeko is chose to partner Lautaro Martinez, as Juventus and Inter face off in the first leg of the Coppa Italia semi-final.
It kicks off at the Allianz Juventus Stadium at 20.00 UK time (19.00 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
This is the only round of the competition to be played over two legs, but as of this season, the away goals rule no longer applies.
That means if the score is level on aggregate after the second match on April 26, the teams go to extra time.
The Derby d’Italia was only played in Serie A on March 19 at San Siro, Juve emerging 1-0 winners after a contentious Filip Kostic goal, as there were suspicions of Adrien Rabiot handball.
They also met in last season’s finals of the Coppa Italia and Supercoppa Italiana, Inter lifting both trophies after extra time.
Paul Pogba and Leonardo Bonucci are still injured, while Federico Chiesa is only fit for the bench, but Di Maria, Vlahovic and Kostic all return to the starting XI.
Inter miss Hakan Calhanoglu and Milan Skriniar, but Federico Dimarco is back and Danilo D’Ambrosio is available because his Serie A ban doesn’t apply to the Coppa Italia.
Dzeko steps in for Romelu Lukaku and Samir Handanovic takes the gloves for this tournament.
Juventus: Perin; Gatti, Bremer, Danilo; Cuadrado, Fagioli, Locatelli, Rabiot, Kostic; Di Maria; Vlahovic
Inter: Handanovic; D’Ambrosio, Acerbi, Bastoni; Darmian, Barella, Brozovic, Mkhitaryan, Dimarco; Dzeko, Lautaro Martinez