Rafael Leao returns to the Milan XI for a Champions League game against Real Madrid, while Yunus Musah is expected to start on the right wing.
It kicks off at 21:00 CET (19:00 GMT) at the Estadio Bernabeu in Madrid.
The Rossoneri have three points in the opening three Champions League games, while Madrid have six.
Matteo Gabbia, Ismael Bennacer and Alessandro Florenzi are unavailable for the Rossoneri. Luka Jovic is not on their UEFA list, but Tammy Abraham is back after recovering from a shoulder injury.
Leao was benched in three consecutive Serie A games, but Paulo Fonseca confirmed at a Monday-match press conference that the Portuguese would start against the Merengues.
Christian Pulisic will begin as an attacking midfielder, and his compatriot Musah will likely get the nod on the right flank.
Former Real Madrid striker Alvaro Morata will start in attack and expects a hostile reception from his ex-fans.
Real Madrid are without David Alaba, Thibaut Courtois and Dani Carvajal.
Real Madrid vs Milan – where to watch on TV
Fans in the UK can watch the game live on TNT Sports 4 and stream it on Discovery+ and Discovery+ App. The live stream in the USA is on Paramount+.
Real Madrid vs Milan – probable line-ups
Real Madrid (4-3-3): Lunin; Lucas Vazquez, Militao, Rudiger, Mendy; Valverde, Tchouameni, Bellingham; Rodrygo, Mbappé, Vinicius.
Milan (4-2-3-1): Maignan; Emerson Royal, Thiaw, Tomori, Theo Hernandez; Fofana, Reijnders; Musah, Pulisic, Leao; Morata.
how funny no Italians in Milans starting 11. shame on them ,should be a rule where you ;MUST;play atleast 5 italians in the starting 11