Napoli are in crisis and turn to Giovanni Simeone and Kvicha Kvaratskhelia in a decimated squad against rock bottom Salernitana, as Piotr Zielinski is out too.
It kicks off at the Stadio Diego Armando Maradona at 14.00 GMT.
The title holders managed one point from three rounds and the 3-0 defeat to Torino proved the final straw, the entire squad put into a week-long training retreat to help prepare for this game and the upcoming Supercoppa Italiana.
Pasquale Mazzocchi was sent off four minutes into his debut after the transfer from Salernitana and is therefore suspended against his former club.
Victor Osimhen and Andre Frank Zambo Anguissa are on international duty, with Alex Meret, Natan, Mathias Olivera and at the last minute Piotr Zielinski injured.
Simeone gets the nod upfront rather than Giacomo Raspadori.
Salernitana remain rock bottom, although coach Pippo Inzaghi has definitely overseen improvement lately.
They held Milan to a 2-2 draw, beat Verona away from home and were only defeated by a last-gasp Juventus goal.
The Africa Cup of Nations has affected them too, taking away Boulaye Dia, Lassana Coulibaly and Jovane, with Giulio Maggiore suspended.
Lorenzo Pirola and Grigoris Kastanos are on the treatment table, so Agustin Martegani gets a rare start.
Loum Tchaouna supports Nwankwo Simy upfront, with veteran Antonio Candreva in a forward role.
The other big news is the return of Guillermo Ochoa in goal for the first time since mid-November.
When these sides met here last season, a surprise 2-2 draw delayed the Scudetto celebrations.
Napoli: Gollini; Di Lorenzo, Rrhamani, Juan Jesus, Mario Rui; Cajuste, Lobotka, Gaetano; Politano, Simeone, Kvaratskhelia
Salernitana: Ochoa; Lovato, Fazio, Gyomber; Martegani, Sambia, Legowski, Bradaric; Tchaouna, Candreva; Simy
Player statistic
29' | Antonio Candreva (Assist: Domagoj Bradaric) | |||
Jens Cajuste | 34' | |||
43' | Mateusz Legowski | |||
Matteo Politano | 45+4' |
Amir Rrahmani | 90+6' | |||
Amir Rrahmani | 90+7' | |||
Khvicha Kvaratskhelia | 90+10' | |||
90+5' | Domagoj Bradaric |