Paulo Dybala and Romelu Lukaku lead the way for Roma in this head-to-head for European ambitions with Charles De Ketelaere and Aleksei Miranchuk’s Atalanta.
It kicks off at the Stadio Olimpico at 19.45 GMT.
With Fiorentina losing and Bologna held to a draw this weekend, it is a big opportunity for both these teams to close the gap on fourth place.
However, the Africa Cup of Nations has taken away Evan Ndicka, Houssem Aouar and Ademola Lookman.
Renato Sanches, Chris Smalling, Tammy Abraham and Marash Kumbulla remain on the treatment table, with Roma also having to prepare for next week’s Coppa Italia quarter-final against local rivals Lazio.
They were in action on Wednesday with a late comeback Coppa Italia win against Cremonese.
Leandro Paredes received a knock to the ankle in that game and is only fit for the bench.
Atalanta won three of their last four Serie A matches and disposed of Sassuolo 3-1 in the Coppa Italia, setting up Wednesday’s clash with Milan.
Rafael Toloi, Jose Luis Palomino, Hans Hateboer and El Bilal Toure are out, so they are down to the bare bones in defence.
Teun Koopmeiners pulls the strings behind Miranchuk and De Ketelaere, as Gianluca Scamacca is on the bench.
Roma: Rui Patricio; Kristensen, Mancini, Llorente; Karsdorp, Bove, Cristante, Pellegrini, Zalewski; Dybala, Lukaku
Atalanta: Carnesecchi; Scalvini, Djimsiti, Kolasinac; Holm, De Roon, Ederson, Ruggeri; Koopmeiners; Miranchuk, De Ketelaere
Player statistic
| 8' |  |
Teun Koopmeiners (Assist: Aleksey Miranchuk) | ||
| 29' |  |
Giorgio Scalvini | ||
| 38' | |
Matteo Ruggeri | ||
| Paulo Dybala |  |
39' | ||
| 43' | |
Éderson |
| 55' | |
Teun Koopmeiners | ||
| Rasmus Kristensen | |
63' | ||
| 74' | |
Davide Zappacosta | ||
| 90' | |
Emil Holm |
Match statistic
