It is a potential Scudetto showdown with Gianluca Scamacca’s Atalanta yet to concede at home this season, hosting Lautaro Martinez and Marcus Thuram for leaders Inter.
It kicks off at the Gewiss Stadium in Bergamo at 17.00 GMT.
La Dea are in fourth place and yet to concede a single goal on home turf this season, but face their toughest test yet with leaders Inter.
Jose Luis Palomino and El Bilal Toure are still out of action, while Giorgio Scalvini is struggling with a recurring back issue.
Scamacca had been close to joining Inter over the summer, but opted for Atalanta instead and has rediscovered his form, partnered by Ademola Lookman and Teun Koopmeiners, sending Charles De Ketelaere to the bench.
Inter rest Alessandro Bastoni against his old club ahead of the Champions League trip to RB Salzburg, while Juan Cuadrado and Marko Arnautovic are injured.
Henrikh Mkhitaryan returns to midfield in place of Davide Frattesi, while Lautaro Martinez leads the way with on-form Marcus Thuram.
Atalanta have a surprisingly poor record against their Lombardy neighbours, managing just five competitive draws and as many defeats since the 4-1 win in November 2018.
Atalanta: Musso; Scalvini, Djimsiti, Kolasinac; Zappacosta, De Roon, Ederson, Ruggeri; Koopmeiners; Lookman, Scamacca
Inter: Sommer; Pavard, De Vrij, Acerbi; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Lautaro Martinez, Thuram
Player statistic
| Marten de Roon |  |
26' | ||
| Sead Kolasinac | |
35' | ||
| 40' |  |
Hakan Calhanoglu |
| 57' |  |
Lautaro Martínez (Assist: Henrikh Mkhitaryan) | ||
| Gianluca Scamacca (Assist: Ademola Lookman) |
|
61' | ||
| Rafael Tolói | |
85' | ||
| 89' | |
Denzel Dumfries | ||
| Rafael Tolói |  |
90+2' |
Match statistic
