Lazio are without Ciro Immobile, so Taty Castellanos and Mateo Guendouzi start in this head-to-head with Charles De Ketelaere and Gianluca Scamacca’s Atalanta.
It kicks off at the Stadio Olimpico at 14.00 UK time (13.00 GMT).
You can follow all the build-up and action as it happens from today’s Serie A games on the LIVEBLOG.
Maurizio Sarri managed to snatch a late Champions League victory away to Celtic midweek, but in Serie A their situation is far more concerning.
The 2-0 defeat to Milan left them closer to the relegation zone than Europe with just seven points from as many games.
Immobile’s muscular problem has flared up again, so he is replaced in attack by Castellanos, flanked by Felipe Anderson and Mattia Zaccagni.
Guendouzi steps into midfield with Luis Alberto.
Atalanta also won on their travels with Thursday’s 2-1 Europa League result away to Sporting CP.
Gianluca Scamacca made his comeback as a substitute in that game and is now in the starting XI with Charles De Ketelaere, while Rafael Toloi has joined El Bilal Toure on the absentee list.
Teun Koopmeiners looked tired against Sporting and is rested for Mario Pasalic.
Lazio: Provedel; Marusic, Casale, Romagnoli, Hysaj; Guendouzi, Rovella, Luis Alberto; Felipe Anderson, Castellanos, Zaccagni
Atalanta: Musso; Scalvini, Djimsiti, Kolasinac; Zappacosta, De Roon, Ederson, Ruggeri; Pasalic; De Ketelaere, Scamacca
Player statistic
| Charles De Ketelaere |  |
5' | ||
| Taty Castellanos (Assist: Felipe Anderson) |
 |
11' | ||
| 33' | |
Éderson (Assist: Matteo Ruggeri) |
| 63' | |
Sead Kolasinac (Assist: Teun Koopmeiners) | ||
| 79' |  |
Matteo Ruggeri | ||
| Matías Vecino (Assist: Taty Castellanos) |
|
83' | ||
| Matías Vecino | |
84' |
Match statistic
