Juventus drop Dusan Vlahovic to start Arkadiusz Milik with Federico Chiesa and bring in Daniele Rugani for the defence against surprise third-place outfit Lecce.
It kicks off at the Allianz Juventus Stadium at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Bianconeri are coming off a 4-2 defeat to Sassuolo, which included a pair of Wojciech Szczesny howlers and a truly comical Federico Gatti own goal.
Paul Pogba is suspended after failing a doping test, with Alex Sandro and Mattia De Sciglio injured for at least six weeks.
Max Allegri makes numerous changes, including sending Gatti to the bench for Daniele Rugani’s first appearance of the season, while Milik replaces ill-tempered Vlahovic as a partner to Chiesa.
Moise Kean is not in the squad, but Andrea Cambiaso returns on the left flank.
Lecce are without doubt the surprise package of the season so far, as along with leaders Inter they are the only side still unbeaten.
They defeated Lazio, Salernitana and Genoa, as well as drawing away to Fiorentina and Monza.
Lameck Banda is out injured, so Pontus Almqvist completes the trident attack with Gabriel Strefezza and form striker Nikola Krstovic.
It has been a great start to the Lecce experience for 23-year-old Krstovic, who scored three goals in just four Serie A appearances.
Federico Baschirotto returns from suspension to bolster the back four.
Juventus: Szczesny; Danilo, Bremer, Rugani; McKennie, Fagioli, Locatelli, Rabiot, Cambiaso; Chiesa, Milik
Lecce: Falcone; Venuti, Pongracic, Baschirotto, Dorgu; Oudin, Ramadani, Blin; Almqvist, Krstovic, Strefezza
Player statistic
| 30' |  |
Ylber Ramadani |
| Arkadiusz Milik (Assist: Adrien Rabiot) |
 |
57' | ||
| 69' | |
Hamza Rafia | ||
| Federico Chiesa | |
76' | ||
| 85' | |
Mohamed Kaba | ||
| Adrien Rabiot | |
90+1' | ||
| 90' | |
Nikola Krstovic | ||
| 90+3' |  |
Mohamed Kaba |
Match statistic
