Juventus can go into second place with a victory, while Napoli need to shake off their Champions League exit, as Arkadiusz Milik faces Victor Osimhen.
It kicks off at the Allianz Juventus Stadium in Turin at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Bianconeri had an ideal week so far, as they reached the Europa League semi-finals after a 1-1 draw away to Sporting CP and above all partially won their appeal against a 15-point Serie A penalty.
It could still be returned before the end of the season, pending a new trial, but for now they are third and a win would put them second because Lazio lost to Torino last night.
Moise Kean is still out of action and Gleison Bremer not at 100 per cent, so Arkadiusz Milik starts with Matias Soule, resting Dusan Vlahovic and Angel Di Maria for Wednesday’s Coppa Italia semi-final against Inter.
Napoli were held in Serie A by Verona and then went out of the Champions League quarter-final to Milan, albeit with question marks over a penalty appeal.
They have to focus on locking down the Scudetto now, with Giovanni Simeone, Mario Rui and Matteo Politano ruled out by injury.
Amir Rrahmani isn’t fully fit either, so Juan Jesus steps in, while Chucky Lozano completes the trident with Kvicha Kvaratskhelia and Osimhen.
When these sides met on January 13, Napoli emerged 5-1 winners to consolidate their Scudetto credentials.
Juventus: Szczesny; Gatti, Rugani, Danilo; Cuadrado, Miretti, Locatelli, Rabiot, Kostic; Soule, Milik
Napoli: Meret; Di Lorenzo, Kim Min-jae, Juan Jesus, Olivera; Anguissa, Lobotka, Ndombele; Lozano, Osimhen, Kvaratskhelia
Player statistic
| Manuel Locatelli |  |
23' | ||
| Adrien Rabiot | |
40' |
| Nicolò Fagioli | |
85' | ||
| Ángel Di María | |
89' | ||
| 90+3' |  |
Giacomo Raspadori (Assist: Eljif Elmas) | ||
| 90+5' | |
Frank Anguissa |
Match statistic
