Joaquin Correa partners Lautaro Martinez with Henrikh Mkhitaryan again in midfield as Inter visit a Fiorentina side with Arthur Cabral and Christian Kouame.
It kicks off at the Stadio Artemio Franchi at 19.45 UK time (18.45 GMT).
The Nerazzurri have to focus on climbing back up the Serie A table, also knowing a win against Viktoria Plzen next week would guarantee progress to the Champions League Round of 16.
Romelu Lukaku, Marcelo Brozovic, Samir Handanovic and Roberto Gagliardini are still out of action, while Dzeko is rested now that Tucu Correa is able to start following his injury.
Once again, Mkhitaryan, Hakan Calhanoglu and Nicolò Barella form the midfield.
Fiorentina are extraordinarily unpredictable, able to crush Hearts 3-0 and 5-1 in the Conference League, but also win only one of their last nine Serie A matches.
Recent form has been particularly poor, losing 4-0 to Lazio and held 1-1 by newly-promoted Lecce.
Gaetano Castrovilli and Riccardo Sottil are injured, with Luka Jovic not 100 per cent fit due to a hip issue, so Arthur Cabral leads the attack with support from Kouame and Nico Gonzalez.
The Viola have not beaten Inter since a 5-4 thriller here in April 2017, followed by five draws and seven defeats, home and away in all competitions.
Fiorentina: Terracciano; Dodo, Milenkovic, Martinez-Quarta, Biraghi; Bonaventura, Amrabat, Duncan; Gonzalez, Cabral, Kouame
Inter: Onana; Skriniar, De Vrij, Acerbi; Darmian, Barella, Calhanoglu, Mkhitaryan, Dimarco; Lautaro Martinez, Correa