New Bologna coach Thiago Motta changes system to 4-2-3-1 and Marko Arnautovic has recovered to start against Empoli.
It kicks off at the Stadio Dall’Ara at 14.00 UK time (13.00 GMT).
The Rossoblu sacked Sinisa Mihajlovic last week and had a caretaker in charge during the 2-1 win over Fiorentina, their first victory of the campaign.
Adama Soumaoro and Nicola Sansone are on the treatment table, but Capocannoniere Arnautovic has shaken off a knock to start.
Empoli have Jean-Daniel Akpa Akpro suspended, with Mattia Destro, Lorenzo Tonelli, Tyronne Ebuehi and Tommaso Baldanzi injured.
Bologna: Skorupski; De Silvestri, Posch, Lucumi, Cambiaso; Medel, Schouten; Orsolini, Soriano, Barrow; Arnautovic
Empoli: Vicario; Stojanovic, Ismajli, Luperto, Parisi; Haas, Marin, Bandinelli; Bajrami; Lammers, Satriano