Fiorentina field an all-attack team in the absence of Gonzalo Rodriguez, but new Palermo Coach Eugenio Corini has to revamp.
It kicks off at the Stadio Franchi at 19.45 GMT, follow the build-up and action on the Liveblog.
The Viola are fresh from two consecutive defeats in all competition to PAOK and Inter, leaking seven goals and scoring four.
Rodriguez is suspended, so Coach Paulo Sousa switches to three at the back with Carlos Salcedo.
Fiorentina field an all-attack team in the absence of Gonzalo Rodriguez, but new Palermo Coach Eugenio Corini has to revamp.
It kicks off at the Stadio Franchi at 19.45 GMT, follow the build-up and action on the Liveblog.
The Viola are fresh from two consecutive defeats in all competition to PAOK and Inter, leaking seven goals and scoring four.
Rodriguez is suspended, so Coach Paulo Sousa switches to three at the back with Carlos Salcedo.
Fiorentina are certainly not holding back, as they use Federico Bernardeschi, Josip Ilicic, Cristian Tello, Khouma Babacar and Nikola Kalinic simultaneously.
Palermo make their debut under new boss Corini, having fired Roberto De Zerbi after a club record seven consecutive Serie A victories.
President Maurizio Zamparini had originally put his faith in De Zerbi, but pulled the plug after midweek Coppa Italia elimination at the hands of Spezia.
Corini’s options are very limited in Florence, as Alessandro Diamanti, Edoardo Goldaniga and Giancarlo Gonzalez are all suspended.
Aleksandar Trajkovski, Accursio Bentivegna and Slobodan Rajkovic are also unavailable.
He moves to three in defence as well, using Robin Quaison to support hitman Ilija Nestorovski.
Fiorentina: Tatarusanu; Salcedo, Astori, Tomovic; Bernardeschi, Vecino, Borja Valero, Tello; Ilicic; Babacar, Kalinic
Palermo: Posavec; Cionek, Andelkovic, Pezzella; Morganella, Hilijemark, Jajalo, Chochev, Aleesami; Quaison; Nestorovski