Juventus seek an 11th consecutive Serie A victory to keep up with Napoli, but Luciano Spalletti transforms Roma.
It kicks off at 19.45 GMT in Turin, follow the action as it happens and give your views on our LIVEBLOG.
The Bianconeri have the opportunity to stay within two points of leaders Napoli, but above all break four points clear of Inter and Fiorentina in third.
Juventus seek an 11th consecutive Serie A victory to keep up with Napoli, but Luciano Spalletti transforms Roma.
It kicks off at 19.45 GMT in Turin, follow the action as it happens and give your views on our LIVEBLOG.
The Bianconeri have the opportunity to stay within two points of leaders Napoli, but above all break four points clear of Inter and Fiorentina in third.
Andrea Barzagli is back from injury, so only Mario Lemina and Roberto Pereyra are still on the treatment table.
Patrice Evra, Sami Khedira, Paulo Dybala and Mario Mandzukic were rested for Wednesday’s 1-0 Coppa Italia quarter-final win away to Lazio, but all return to the starting XI.
Roma made their debut last week under Spalletti, held to a 1-1 draw by Hellas Verona, but this time round the new Coach gets to make a bigger impact.
He has transformed their tactics into a 3-4-1-2 system – though it could go 3-4-2-1 – with Radja Nainggolan in the trequartista slot supporting Mohamed Salah and Edin Dzeko.
The big change is in the three-man defence, with Daniele De Rossi dropping back, so Lucas Digne and Alessandro Florenzi can focus more on attack.
Gervinho, of course, is dropped because he's in negotiations for a transfer to Chinese club Jiangsu Suning.
Douglas Maicon, Salih Ucan and Kevin Strootman are injured.
The most recent Roma victory away to Juventus in Serie A was 2-1 on January 23 2010, precisely six years and one day ago.
It was followed by a 1-1 draw and four consecutive defeats. Since 1994-95, there have been 27 red cards in Serie A games between Roma (13) and Juve (14).
Juventus: Buffon; Barzagli, Bonucci, Chiellini; Lichtsteiner, Khedira, Marchisio, Pogba, Evra; Dybala, Mandzukic
Juventus bench: Neto, Audero, Caceres, Rugani,Hernanes, Padoin, Sturaro, Asamoah, Cuadrado, Alex Sandro, Morata, Zaza
Roma: Szczesny; Manolas, De Rossi, Rudiger; Florenzi, Pjanic, Vainqueur, Digne; Nainggolan; Salah, Dzeko
Roma bench: De Sanctis, Lobont, Torosidis, Castan, Gyomber, Keita, Emerson, Falque, Totti, Sadiq