Milan are forced to completely transform their midfield and consequently drop Patrick Cutrone against Federico Chiesa’s fired-up Fiorentina.
It kicks off at San Siro at 14.00 GMT.
You can follow the build-up and action as it happens from all 10 Serie A games on the LIVEBLOG.
Gennaro Gattuso remains under serious pressure after the Europa League exit to Olympiacos, plus back-to-back 0-0 draws with Torino and lowly Bologna.
Milan are forced to completely transform their midfield and consequently drop Patrick Cutrone against Federico Chiesa’s fired-up Fiorentina.
It kicks off at San Siro at 14.00 GMT.
You can follow the build-up and action as it happens from all 10 Serie A games on the LIVEBLOG.
Gennaro Gattuso remains under serious pressure after the Europa League exit to Olympiacos, plus back-to-back 0-0 draws with Torino and lowly Bologna.
To make matters worse, Franck Kessie and Tiemoue Bakayoko are both suspended, removing two of his first choice midfielders.
Lucas Biglia, Giacomo Bonaventura, Fabio Borini and Mattia Caldara remain injured, with Andrea Bertolacci the natural choice to come in – until he too got hurt during training.
The options are so limited that Jose Mauri is given the nod with Davide Calabria moved up and Hakan Calhanoglu pushed back to complete a makeshift midfield.
The 4-4-2 is scrapped in favour of Gattuso’s original 4-3-3 idea, with Gonzalo Higuain flanked by Samu Castillejo and Suso, benching Cutrone.
Fiorentina are back in the running for a Europa League spot after ending the negative streak and can count on Jordan Veretout, Nikola Milenkovic and Edimilson Fernandes, who all return from suspension.
Kevin Mirallas has scored in each of his last two appearances, so retains his place in the trident with Giovanni Simeone and Federico Chiesa.
The Viola have lost each of their last three Serie A visits to Milan and a fourth would be their worst run here since 1997.
A smart bet might be a draw, seeing as Fiorentina have shared the spoils in each of their last four away fixtures.
Milan: G Donnarumma; Abate, Romagnoli, Zapata, Rodriguez; Calabria, Mauri, Calhanoglu; Suso, Higuain, Castillejo
Milan bench: Reina, A Donnarumma, Conti, Montolivo, Musacchio, Cutrone, Halilovic, Laxalt, Brescianini, Tsadjout
Fiorentina: Lafont; Milenkovic, Pezzella, Vitor Hugo, Biraghi; Edimilson Fernandes, Veretout, Benassi; Chiesa, Simeone, Mirallas
Fiorentina bench: Dragowski, Laurini, Ceccherini, Norgaard, Eysseric, Gerson, Pjaca, Dabo, Maxi Olivera, Hancko, Vlahovic, Thereau
Ref: Mariani