Lazio rely on Sergej Milinkovic-Savic, Joaquin Correa and Vedat Muriqi, as they miss Ciro Immobile and other stars against Zenit St Petersburg.
It kicks off at 17.55 GMT, you can follow the build-up and action as it happens from this game and Ferencvaros-Juventus on the LIVEBLOG.
Lazio rely on Sergej Milinkovic-Savic, Joaquin Correa and Vedat Muriqi, as they miss Ciro Immobile and other stars against Zenit St Petersburg.
It kicks off at 17.55 GMT, you can follow the build-up and action as it happens from this game and Ferencvaros-Juventus on the LIVEBLOG.
Simone Inzaghi’s men are still unbeaten in the Champions League, having defeated Borussia Dortmund and then earned a 1-1 draw at Club Brugge, despite a COVID-19 outbreak within the squad.
There is a great deal of confusion here, as the UEFA tests for Coronavirus appear to be more sensitive or more prone to error than the Serie A ones.
So while Luis Alberto, Manuel Lazzari and Djavan Anderson appear to have COVID-19, the UEFA tests for Immobile, Lucas Leiva and Thomas Strakosha are only positive on the UEFA tests.
Stefan Radu and Senad Lulic are also long-term injury cases, so Muriqi partners Tucu Correa, leaving Andreas Pereira on the bench.
Zenit have plenty of problems too, having lost both Champions League games so far, 2-1 at home to Club Brugge and 2-0 away to Borussia Dortmund.
There are injuries ruling out Sardar Azmoun, Malcom and Sebastian Driussi, so Artem Dyuba is the only real option upfront.
Due to the difference in lockdown rules, Zenit can have 20,000 fans in their stadium.
Zenit: M Kerzhakov; Karavaev, Lovren, Rakitskiy, Douglas Santos; Zirkhov, Barrios, Erokhin; Kuzyaev, Dzyuba, Ozdoev
Zenit bench: Vasyutin, Linev, Krugovoi, Mostovoy, Sutormin, Wendel, Prokhin, Shamkin
Lazio: Reina; Patric, Hoedt, Acerbi; Marusic, Akpa Akpro, Parolo, Milinkovic-Savic, Fares; Correa, Muriqi
Lazio bench: Furlanetto, Alia, Luiz Felipe, Pereira, Armini, Caicedo, Cataldi, Bertini, Czyz, Franco, Pica
Ref: Artur Dias (POR)